Results 281 to 290 of about 100,010 (342)

Antibody-drug conjugates in breast cancer: mechanisms of resistance and future therapeutic perspectives. [PDF]

NPJ Breast Cancer
Valle I, Grinda T, Antonuzzo L, Pistilli B.   +3 more
europepmc   +1 more source

Pharmacokinetics of FK 506 in transplant patients [PDF]

, 1991
Abu-Elmagd, K, Alessiani, M, Flowers, J, Fung, J, Jain, A, Krajak, A, Lever, J, Mehta, S, Starzl, TE, Todo, S, Venkataramanan, R, Warty, VS, Zuckerman, S   +12 more
core  

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

In Silico Structural Analysis of Human β-Glucuronidase for Antibody-Drug Conjugates Optimization. [PDF]

Proteins
Canini G, Saporiti S, Coppa C, Rossi M, Centola F, Arcovito A.   +5 more
europepmc   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Antibody-drug conjugates in cancer therapy: current landscape, challenges, and future directions. [PDF]

Mol Cancer
Chen B, Zheng X, Wu J, Chen G, Yu J, Xu Y, Wu WKK, Tse GMK, To KF, Kang W.   +9 more
europepmc   +1 more source

Coacervates Made of Elastin‐Like Polypeptides Fused with Melanocyte‐Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord‐Injured Mice

Advanced Healthcare Materials, EarlyView.
Pressure skin wounds are frequent complications after spinal cord injury (SCI), with impaired healing due to vascular and immune deficits. Elastin‐like polypeptides (ELP) fused to α‐MSH (MSH‐ELP) or MCP‐1 (MCP‐ELP) are developed and tested on these wounds. The resulting nanoparticles are non‐toxic and bioactive, and they enhance macrophage recruitment,
Suneel Kumar, Dhruv Patel, Greeshma Manjunath, Shashank Madhavan, Ashley Mathew, Dnyaneshwari Rananavare, Jahnavi Shah, Francois Berthiaume   +7 more
wiley   +1 more source

Supervisory signals are intriguingly high in even simple features for predicting anticancer effect of antibody drug conjugates. [PDF]

Brief Bioinform
Nagpal S.
europepmc   +1 more source

Smart Catheters for Diagnosis, Monitoring, and Therapy

Advanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman, Samiha Ahmed, Majed Othman Althumayri, Megan Guy, Darlenne Chavez Lugo, Frances S. Ligler, George T. Ligler, Rahmi Oklu, Hiroshi Kawahira, Michael J. McShane, Jun Kameoka, Jonathan Bova, Hatice Ceylan Koydemir   +12 more
wiley   +1 more source

Determinants of sensitivity to HER2-targeted antibody drug conjugates in urothelial cancer. [PDF]

Nat Commun
Chen Z, Tang X, Eichholz JE, Mcpherson A, Thomas J, Nagar K, Rustgi N, Christin JR, Kuo F, Gao S, Jiang H, Luo J, Ostrovnaya I, Basar M, Pietzak E, Coleman JA, Berger MF, de Stanchina E, Shah SP, Mohibullah N, Aggen DH, Rosenberg JE, Chandarlapaty S, Shen MM, Al-Ahmadie H, Iyer G, Kim K, Solit DB.   +27 more
europepmc   +1 more source