Results 131 to 140 of about 2,312,760 (293)

Characterisation of HLA-specific antibodies [PDF]

A successful kidney transplant is the best treatment for established renal failure, yet around 300 patients per annum are denied transplants because they have antibodies, most notably directed against donor HLA or ABO in their blood, which have the ...
Lowe, David Philip
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Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Impact of Transient and Persistent Donor-Specific Antibodies in Lung Transplantation

Transplant International
Lung transplantation (LuTx) is an established treatment for patients with end-stage lung diseases, however, outcomes are limited by acute and chronic rejection.
S. Auner, C. Hillebrand, P. M. Boehm, J. Boecker, D. Koren, S. Schwarz, Z. Kovacs, G. Murakoezy, G. Fischer, C. Aigner, K. Hoetzenecker, P. Jaksch, A. Benazzo   +12 more
doaj   +1 more source

Engineered immunostimulatory H2O2‐producing microreactors driven by yeast as localized living cancer therapeutics

BMEMat, EarlyView.
Engineered yeast microreactors that produce H2O2 within tumors enable selective cancer cell killing while releasing immunostimulatory components, effectively suppressing local tumor growth and activating systemic antitumor immunity, with further efficacy enhanced by anti‐PD‐1 therapy and transarterial embolization.
Wenqian He, Chunjie Wang, Minming Chen, Weihao Yang, Bin Yu, Yuhang Hu, Hengze Ding, Yifan Yan, Zhijuan Yang, Liangzhu Feng   +9 more
wiley   +1 more source

Zbtb7a induction in alveolar macrophages is implicated in anti-HLA–mediated lung allograft rejection

, 2017
Zbtb7a in alveolar macrophages influences early inflammation and autoimmunity in antibody-mediated rejection of transplanted lungs.
Ramsey Hachem, Jing Huang, Thalachallour Mohanakumar, Min Xu, Michael A. Smith, Fangyu Zhou, Ross M. Bremner, Deepak K. Nayak, Andrew E. Gelman, Jinsheng Yu, Moriya Tsuji   +10 more
core   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation

, 2009
Background. The aim of this study was to examine the development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation in relation to the Banff 07 histological classification. Methods.
Briggs, David, Imray, C. (Chris), Lam, For T., Fletcher, Simon, McKinnell, Joanna, Krishnan, Nithya, Chen, Klaus, Lowe, David Philip, Hamer, Rizwan, Zehnder, Daniel, Kashi, Habib, Higgins, Rob, Tan, Lam Chin, D. Zehnder, R. Higgins, F. T. Lam, L. C. Tan, H. Kashi, J. McKinnell, R. Hamer, S. Fletcher, D. Lowe, C. Imray, D. Briggs, N. Krishnan, K. Chen   +25 more
core   +1 more source

Review of articular cartilage repair techniques and their application in the horse

Equine Veterinary Journal, EarlyView.
Abstract Articular cartilage lesions represent a significant career‐limiting problem in athletic horses. A healthy articular cartilage surface is vital for optimal joint function, and defects can result in irreversible degenerative changes. Successful treatment of cartilage lesions remains a long‐standing challenge for orthopaedic surgeons, prompting ...
Charlotte K. Barton, Brad B. Nelson, Laurie R. Goodrich   +2 more
wiley   +1 more source

The Treatment of Acute Antibody-Mediated Rejection: Current State and Future Perspectives

Despite the advances in the immunosuppressive therapies and improvements in short term allograft survival, Antibody-mediated rejection (AMR) still represents the leading cause of late allograft failure in kidney transplant recipients.
Maggiore U., Fiaccadori E., Benigno G. D., Gandolfini I., Delsante M., Gentile M., Palmisano A., D'angelo M.   +7 more
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