Results 101 to 110 of about 1,768,583 (320)
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
B cell-helping functions of gut microbial metabolites
Microbial Cell, 2016 Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR).
Chang H. Kim
doaj +1 more source
(5) Kinetics and Significance of Auto-antibody Producing Cell
Japanese Journal of Medicine, 1972 The mechanism of the development of autoimmune diseases still remains unknown, but if such diseases result from the impairment of cells or tissues by the auto-antibody, the clue to the elucidation of the entities of autoimmune diseases lies in the identification of the cells producing the auto-antibody and clarification of their kinetics.
openaire +6 more sources
Studies on Antibody-Producing Cells by Hemolytic Plaque Method and Phase Contrast Microscopy [PDF]
, 1969 Kiyohiro Irimajiri +3 more
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Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Monoclonal Antibodies: Producing Magic Bullets by Somatic Cell Hybridization [PDF]
The Journal of Immunology, 2005 “The really profound changes in human life all have their ultimate origin in knowledge pursued for its own sake.” Albert N. Whitehead ([1][1]) We purchase them through catalogs and online suppliers; we mail them in polypropylene tubes; we pass them surreptitiously from hand to pocket ...
openaire +3 more sources
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Cell Reports, 2019 Summary: Mechanisms that govern transcriptional regulation of inflammation in atherosclerosis remain largely unknown. Here, we identify the nuclear transcription factor c-Myb as an important mediator of atherosclerotic disease in mice.
Eric A. Shikatani +30 more
doaj +1 more source
Studies on the Role of Serotonin and Mast Cells in Anaphylaxis of the Mouse Produced with Soluble Antigen-Antibody Complexes [PDF]
, 1961 S. Tokuda, Russell S. Weiser
openalex +1 more source