Results 71 to 80 of about 1,768,583 (320)
The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells
Frontiers in Immunology, 2018 BackgroundT follicular helper (Tfh) cells are key players in the production of antibody-producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells are important where antibody formation is implicated in disease, such ...
Elizabeth F. Wallin +4 more
doaj +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Division and differentiation of natural antibody-producing cells in mouse spleen [PDF]
Proceedings of the National Academy of Sciences, 2007 B-1a cells reside in both the peritoneal cavity and the spleen. LPS stimulates splenic B-1a to differentiate to plasma cells producing natural IgM specific for microbial and self antigens. However, there are conflicting views as to whether the B-1a cells divide before this differentiation occurs, and hence how the resident B-1a population ...
Leonard A. Herzenberg +4 more
openaire +3 more sources
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Carrier and Hapten Antibody-Producing Cells, in Vitro I. Cytokinetics
Experimental Biology and Medicine, 1973 SummaryNormal spleen cells or HRBC-primed spleen cells were cultured with HRBC, TNP-HRBC or without an in vitro immunogen. Anti-HRBC and anti-TNP responses were assessed on Days 2, 3, and 4. Antibody-producing cells detected on Day 2 arose mainly from late, on Day 3 from intermediate and on Day 4 from early precursor cell types.
T L, Pazdernik, E M, Uyeki, J, Doull
openaire +3 more sources
The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells
FEBS Letters, EarlyView.The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman +3 more
wiley +1 more source
International Journal of Infectious Diseases, 2015 Objectives: The regulation of the immunopathology of respiratory syncytial virus (RSV) by regulatory T-cells (CD4+CD25+Foxp3+; Tregs) is not understood.
Hsiao-Yun Shao +8 more
doaj +1 more source
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Experimental and Molecular Medicine, 2018 Cancer: Improving targeted therapy A new method for producing antibody-drug conjugates (ADCs), pairing anti-cancer drugs with antibodies that deliver them specifically to cancer cells, may help to develop therapies for hard-to-treat cancers.
Junyeong Jin +5 more
doaj +1 more source