Optimized DNA electroporation for primary human T cell engineering
BMC Biotechnology, 2018 Background Effective gene-delivery systems for primary human T cell engineering are useful tools for both basic research and clinical immunotherapy applications.
Zhang Zhang +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Antibody-Catalyzed Enantioselective Robinson Annulation
, 2016 Antibody-Catalyzed Enantioselective Robinson ...
Guofu Zhong (1508497) +4 more
core +1 more source
Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor
Toxins, 2016 Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li +8 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Augmentation of Antibody Response of lmmune Comlex-Ingested Mononuclear Cells(MNC) by Antigen Specific Antibody [PDF]
, 1993 Anti-S.pyogenes antibodies were examined for their effects on antibody production of mononuclear cells (MNC) which were previously stimulated by the phagocytosis of specific immune complexes.
亀子, 文子, 上原, 良雄
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Early Diagnosis and Successful Treatment of Acute Antibody-Mediated Rejection of a Renal Transplant
, 2011 Antibody-mediated rejection is a delicate situation. it rarely occurs but when it does, it usually results in graft dysfunction and frequently, graft loss.
YANG, YA-WEN;LIN, WEI-CHOU;WU, MING-SHIOU;LEE, PO-HUANG;TSAI, MENG-KUN +1 more
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort [PDF]
, 2013 The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the study were to measure and compare neutralizing antibody responses at different time points in ...
G.F. Medley +11 more
core +1 more source