Results 71 to 80 of about 2,678,192 (313)

Selection of neutralizing antibody escape mutants with type A influenza virus HA-specific polyclonal antisera: possible significance for antigenic drift [PDF]

, 1997
Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition,
Cleveland, S. Matthew, Dimmock, N. J., Taylor, H. P.   +2 more
core   +1 more source

DSG2 expression is low in colon cancer and correlates with poor survival

BMC Gastroenterology, 2021
Background Desmoglein2 (DSG2) is a transmembrane protein that helps regulate intercellular connections and contributes to desmosome assembly. Desmosome are associated with cell adhesion junctions, which play an important role in cancer progression ...
Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao, Zhenqing Feng   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Single scaffold antibody libraries created with high rates of mutagenesis or diversity focused for peptide recognition [PDF]

, 2007
textThis dissertation describes several strategies used to create diversity in non-immune antibody libraries. Two of the strategies were used to create two separate peptide focused libraries.
Cobaugh, Christian Wessel, 1971-
core  

Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex

mAbs
TCR-mimic (TCRm) antibodies represent a promising new frontier in cancer immunotherapy, enabling the targeting of intracellular targets previously considered undruggable with antibodies. We developed an integrated platform for generating human antibodies
Jennifer Watkins-Yoon, Wei-Cheng Lu, Elyse M. Petrunak, Noah J. Tubo, Sara Halmos, William McConaughy, Rodolfo Ciuffa, Cédric Weber, Simon Friedensohn, Sune Justesen, Marie Skovgaard, Rennard Rachel, Caity Goshert, Lucy Liu, Piotr Bobrowicz, Jeffrey J. Molldrem, Dongxing Zha   +16 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Human monoclonal antibody combination against SARS coronavirus : synergy and coverage of escape mutants [PDF]

, 2006
Background: Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible.
Peiris, Joseph S. M., Cox Freek, Doerr, Hans Wilhelm, Brink, Edward van den, van den Brink Edward N, Hans Wilhelm Doerr, ter Meulen Jan, Doerr Hans Wilhelm, Cheung, Chung Y., de Kruif John, van Deventer, Els, Jaap Goudsmit, Leo L. M., Poon, Leo L M Poon, Marissen Wilfred E, Marissen, Wilfred E., Poon Leo L. M, van den Brink, Edward N., Chow Vincent T, Chung Y Cheung, Wolfgang Preiser, Leung, Cynthia S.W., Preiser, Wolfgang, Van Deventer, E, Bogaards Johannes A, Freek Cox, Wilfred E Marissen, Els van Deventer, Joseph S M Peiris, Chow, Tak-Kwong Vincent, Bakker, Arjen Q., Leung, CSW, Chow, Vincent T., de Kruif, John, Goudsmit Jaap, ter Meulen, Jan, Deventer, Els van, Kruif, John de, De Kruif, J, John de Kruif, Cynthia S W Leung, Jan ter Meulen, Bogaards, Johannes A., Cox, F, Preiser Wolfgang, Cox, Freek, Goudsmit, J, Peiris Joseph S. M, Poon, LLM, Cheung, CY, Johannes A Bogaards, Doerr, HW, van Deventer Els, Marissen, WE, Bakker Arjen Q, Peiris, Joseph S.M., Poon, Leo L. M., Leung Cynthia S. W, Chow, VT, Edward N van den Brink, Bogaards, JA, Vincent T Chow, Arjen Q Bakker, Poon, Leo L.M., Cheung Chung Y, Van Den Brink, EN, Peiris, Joseph Sriyal Malik, Ter Meulen, J, Leung, Cynthia S. W., Goudsmit, Jaap, Peiris, JSM, Meulen, Jan ter, Bakker, AQ, Preiser, W   +73 more
core   +1 more source

Immunogenicity of monovalent and multivalent subunit vaccines against SARS-CoV-2 variants in mice with divergent vaccination history

Microbiology Spectrum
There are challenges in selecting SARS-CoV-2 vaccine compositions, primarily due to divergent infection or vaccination history and immunological biases toward previous strains. In this study, we evaluated humoral immune responses induced by variant-based
Rui Wang, Yuan Lyu, Meng Chen, Lili Sun, Shaozheng Zhou, Yudi Cui, Juan Ma, Desheng Kong, Jianbo Lu, Xuefeng Li, Liangzhi Xie   +10 more
doaj   +1 more source

Tetanus Neurotoxin Neutralizing Antibodies Screened from a Human Immune scFv Antibody Phage Display Library

Toxins, 2016
Tetanus neurotoxin (TeNT) produced by Clostridium tetani is one of the most poisonous protein substances. Neutralizing antibodies against TeNT can effectively prevent and cure toxicosis.
Han Wang, Rui Yu, Ting Fang, Ting Yu, Xiangyang Chi, Xiaopeng Zhang, Shuling Liu, Ling Fu, Changming Yu, Wei Chen   +9 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source