Results 51 to 60 of about 2,528,348 (198)

TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway

Cell Communication and Signaling
Background Extracellular heat shock protein 90α (eHSP90α) regulates diverse cellular processes such as wound healing, tumor metastasis, angiogenesis and cell differentiation etc.
Jing Li, Junmin Li, Tong Xie, Shuxin Huang, Haijiao Tian, Mengyun Liu, Xiumei Kong, Dongzhe Zhang, Khan Iqbal Nawaz, Mingli Wang, Hui Li, Jing Zhang, Fengling Yuan, Weikai Guo, Xiukun Cui, Hongmei Mu, Yanzhong Hu   +16 more
doaj   +1 more source

A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan

Journal of Immunology Research, 2019
To improve efficacy and minimize toxicity of EGFR inhibition treatment, we developed Ame55, a novel anti-EGFR IgG1 with lower affinity to EGFR than cetuximab (C225) from a human phage library.
Weiyi Qiu, Chang Zhang, Shuang Wang, Xiaoyan Yu, Qiong Wang, Dadi Zeng, Peng Du, Jinling Ma, Yiqiong Zheng, Bo Pang, Yunzhou Yu, Feng Long, Xiaobin Pang, Zhiwei Sun   +13 more
doaj   +1 more source

Antibody Conjugates via Disulfide Bridging: Towards therapeutic and diagnostic applications [PDF]

, 2015
Antibodies play a prominent role in chemical and biological research and the largest application of chemical bioconjugation reagents is in the production of antibody conjugates.
Hull, EA
core  

i-shaped antibody engineering enables conformational tuning of biotherapeutic receptor agonists

Nature Communications
The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediators, and targeting agents, they are not readily
Matthew G. Romei, Brandon Leonard, Zachary B. Katz, Daniel Le, Yanli Yang, Eric S. Day, Christopher W. Koo, Preeti Sharma, Jack Bevers III, Ingrid Kim, Huiguang Dai, Farzam Farahi, May Lin, Andrey S. Shaw, Gerald Nakamura, Jonathan T. Sockolosky, Greg A. Lazar   +16 more
doaj   +1 more source

A novel built-in adjuvant metallothionein-3 aids protein antigens to induce rapid, robust, and durable immune responses

Frontiers in Immunology, 2022
Adjuvants are crucial components of vaccines that can enhance and modulate antigen-specific immune responses. Herein, we reported for the first time that human metallothionein-3 (MT3), a low molecular weight cysteine-rich metal-binding protein, was a ...
Ying Yin, Yanfei Gu, Xiaodong Zai, Ruihua Li, Xinjie Zhu, Rui Yu, Jun Zhang, Shuyi Wang, Yue Zhang, Jian Lin, Junjie Xu, Wei Chen   +11 more
doaj   +1 more source

Selection of neutralizing antibody escape mutants with type A influenza virus HA-specific polyclonal antisera: possible significance for antigenic drift [PDF]

, 1997
Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition,
Cleveland, S. Matthew, Dimmock, N. J., Taylor, H. P.   +2 more
core   +1 more source

Antibody-escape maps for individuals infected with early 2020 viruses, Beta, or Delta. [PDF]

, 2022
(A) Site-total antibody escape averaged across each group of plasmas for early 2020, Beta, and Delta convalescent plasmas, with key epitope regions highlighted (key in panel C).
Helen Y. Chu (9676313), Alex Sigal (22494), Rachel T. Eguia (10573370), Tyler N. Starr (3276999), Jennifer K. Logue (12060473), Allison J. Greaney (11046384), Nicholas Franko (12976161), Khadija Khan (9315479), Sandra M. Lord (12976164), Cate Speake (644053), Jesse D. Bloom (8796629)   +10 more
core   +1 more source

DSG2 expression is low in colon cancer and correlates with poor survival

BMC Gastroenterology, 2021
Background Desmoglein2 (DSG2) is a transmembrane protein that helps regulate intercellular connections and contributes to desmosome assembly. Desmosome are associated with cell adhesion junctions, which play an important role in cancer progression ...
Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao, Zhenqing Feng   +7 more
doaj   +1 more source

The effect of daily co-trimoxazole prophylaxis on natural development of antibody-mediated immunity against P. falciparum malaria infection in HIV-exposed uninfected Malawian children. [PDF]

, 2015
BACKGROUND AND OBJECTIVES: Co-trimoxazole prophylaxis, currently recommended in HIV-exposed, uninfected (HEU) children as protection against opportunistic infections, also has some anti-malarial efficacy.
Tom Hall (712080), Kamija S Phiri, Gondwe, Thandile, Jambo, Kondwani C, Tetteh, Kevin KA, Longwe, Herbert, Chris Drakeley (79962), Wilson L. Mandala (360369), Drakeley, Chris, Kevin K A Tetteh, Phiri, Kamija S, Chris Drakeley, Nyanyiwe Mbeye, Mandala, Wilson L, Nyanyiwe Mbeye (712078), Tom Hall, Kondwani C. Jambo (159487), Kevin K. A. Tetteh (122339), Wilson L Mandala, Thandile Gondwe (712079), Herbert Longwe (712077), Herbert Longwe, Thandile Gondwe, Mbeye, Nyanyiwe, Kamija S. Phiri (52377), Hall, Tom, Kondwani C Jambo   +26 more
core   +1 more source

Antibody-mediated neutralization of envelope virus. [PDF]

, 2022
SARS-CoV-2 virus entry into human cells is initiated by virus binding to the ACE2-cell surface receptors (point 1). The virus neutralization largely depends on the epitope targeted by antibodies.
Arun Khattri (10306298), Anshumali Mittal (161835), Vikash Verma (144411)   +2 more
core   +1 more source