Results 31 to 40 of about 2,742,093 (316)

Challenges and developments in universal vaccine design against SARS-CoV-2 variants

npj Vaccines, 2022
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had become a global concern because of its unexpectedly high pathogenicity and transmissibility.
Fangxin Zhao, Xiaodong Zai, Zhiling Zhang, Junjie Xu, Wei Chen   +4 more
doaj   +1 more source

A Polysaccharide-RBD-Fc-Conjugated COVID-19 Vaccine, SCTV01A, Showed High Immunogenicity and Low Toxicity in Animal Models

Vaccines, 2023
We previously developed a polysaccharide-–RBD-conjugated nanoparticle vaccine which induced protective efficacy against SARS-CoV-2 in a mouse model. Here, we newly developed a vaccine, SCTV01A, by chemically conjugating recombinant SARS-CoV-2 RBD-Fc and ...
Chunyun Sun, Desheng Kong, Erhong Guo, Jun Zhao, Jilei Jia, Rui Wang, Juan Ma, Meng Chen, Jianbo Lu, Chulin Yu, Kuokuo Li, Liangzhi Xie   +11 more
doaj   +1 more source

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]

, 2013
Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Rizwan Hamer, Imray, C. (Chris), Nithya S Krishnan, Lam Chin Tan, Higgins Robert M., Daga Sunil, Lowe, David Philip, David Briggs, Zehnder Daniel, Tan Lam Chin, Zehnder, Daniel, Robert M Higgins, Daniel Zehnder, Kashi Habib, Dave Lowe, Christopher Imray, Sunil Daga, Neil Raymond, Krishnan, Nithya S., Lam, F. T., Higgins, Rob, Lam F. T., Habib Kashi, Daga, Sunil, F T Lam, Krishnan Nithya S., Lowe Dave, Hamer, Rizwan, Briggs David, Kashi, Habib, Briggs, David, Dr., Raymond Neil, Raymond, Neil T., Hamer Rizwan, Tan, Lam Chin, Imray Christopher   +35 more
core   +1 more source

Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity

, 2023
Antibody–drug conjugates (ADCs) constitute a rapidly expanding category of biopharmaceuticals that are reshaping the landscape of targeted chemotherapy.
Jezabel Garcia-Parra, Lewis Webb Francis, Robert Steven Conlan, Deyarina Gonzalez, Emenike Kenechi Onyido, John Sinfield, Zoe Coombes, Anna Moberg, Nicole Williams, David James, Jenny Worthington   +10 more
core   +1 more source

Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection. [PDF]

, 2010
Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes.
M. PINDER, Dunyo, S, Conway, DJ, O. J. AKPOGHENETA, D. J. CONWAY, Akpogheneta, OJ, Pinder, M, S. DUNYO   +7 more
core   +1 more source

Construction and Immunological Evaluation of an Adenoviral Vector-Based Vaccine Candidate for Lassa Fever

Viruses, 2021
Lassa virus (LASV) is a rodent-borne arenavirus circulating in West African regions that causes Lassa fever (LF). LF is normally asymptomatic at the initial infection stage, but can progress to severe disease with multiorgan collapse and hemorrhagic ...
Meirong Wang, Ruihua Li, Yaohui Li, Changming Yu, Xiangyang Chi, Shipo Wu, Shulin Liu, Junjie Xu, Wei Chen   +8 more
doaj   +1 more source

GPI-Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications [PDF]

Iranian Journal of Immunology, 2019
Background: We have previously reported the aberrant expression of Fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL). Although FMOD has been considered as a cytoplasmic or secretory protein, we discovered the cell surface expression
Lia Farahi, Fatemeh Ghaemimanesh, Saeideh Milani, Seyed Mohsen Razavi, Reza Hadavi, Ali Ahmad Bayat, Ali Salimi, Mohammad Mehdi Akhondi, Hodjattallah Rabbani   +8 more
doaj   +1 more source

Successful targeting of multidrug-resistant tumors with bispecific antibodies

mAbs
Multidrug resistance (MDR) hinders efficacious cancer chemotherapy. Overexpression of the P-glycoprotein (P-gp) efflux pump (EP) on cancer cells is a primary cause of MDR since it expels numerous anticancer drugs.
Raffaella Briante, Qianting Zhai, Suchismita Mohanty, Pingping Zhang, Alissa O’Connor, Hiwot Misker, Willie Wang, Cindy Tan, Mastewal Abuhay, Jessica Morgan, Richard Theolis, Paul Ponath, Robert Arathoon   +12 more
doaj   +1 more source

An integrated mammalian library approach for optimization and enhanced microfluidics-assisted antibody hit discovery

Artificial Cells, Nanomedicine, and Biotechnology, 2023
Recent years have seen the development of a variety of mammalian library approaches for display and secretion mode. Advantages include library approaches for engineering, preservation of precious immune repertoires and their repeated interrogation, as ...
Ramona Gaa, Kavita Kumari, Hannah Melina Mayer, Desislava Yanakieva, Shang-Pu Tsai, Saurabh Joshi, Ralf Guenther, Achim Doerner   +7 more
doaj   +1 more source

A platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodies

mAbs, 2021
Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation of these approaches used for antibody discovery
Ruijun Zhang, Ponraj Prabakaran, Xiaocong Yu, Brian C. Mackness, Ekaterina Boudanova, Joern Hopke, Jose Sancho, Jacqueline Saleh, HyunSuk Cho, Ningning Zhang, Helene Simonds-Mannes, Samuel D. Stimple, Dietmar Hoffmann, Anna Park, Partha S. Chowdhury, Sambasiva P. Rao   +15 more
doaj   +1 more source