Role of hydrophobic interaction in hapten-antibody binding [PDF]
, 1977 The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more
Oda, Takuzo +5 more
core +1 more source
mAbs, 2021 Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation of these approaches used for antibody discovery
Ruijun Zhang +15 more
doaj +1 more source
Antibody Engineering for the Development of Therapeutic Antibodies
Molecules and Cells, 2005 Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical ...
Sang Jick, Kim +2 more
openaire +2 more sources
Successful targeting of multidrug-resistant tumors with bispecific antibodies
mAbsMultidrug resistance (MDR) hinders efficacious cancer chemotherapy. Overexpression of the P-glycoprotein (P-gp) efflux pump (EP) on cancer cells is a primary cause of MDR since it expels numerous anticancer drugs.
Raffaella Briante +12 more
doaj +1 more source
Improving sensitivity of oral fluid testing in IgG prevalence studies: application of mixture models to a rubella antibody survey [PDF]
, 2003 A method for the analysis of age-stratified antibody prevalence surveys is applied to a previously reported survey of antibody to rubella virus using oral fluid samples in which the sensitivity of the assay used was shown to be compromised.
Nigatu, Wondatir +4 more
core +1 more source
Development of Antibody–Oligonucleotide Complexes for Targeting Exosomal MicroRNA [PDF]
, 2020 MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA ...
Ashihara, Eishi +19 more
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An immunohistochemical study of human platelets using a rabbit antibody against H18-K24 of apolipoprotein CIII (HATKTAK) [PDF]
, 2013 香川大学Kagawa University博士（医学）Abstract H18‐K24 of human apolipopotein CIII (Apo CIII) (HATKTAK) is an activator of the macromolecular activators of phagocytosis from platelets (MAPPs).
山中, 隆夫 +2 more
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Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific. [PDF]
, 2008 Naturally acquired antibody responses provide partial protection from clinical malaria, and blood-stage parasite vaccines under development aim to prime such responses. To investigate the determinants of antibody response longevity, immunoglobulin G (IgG)
Conway, David J +13 more
core +1 more source
Antibody production in transgenic plants [PDF]
, 2022 S.301-318Antibodies bind with great affinity and specificity to their target antigens, allowing them to be exploited in research, medicine, agriculture, and industry.
Christou, P. +4 more
core
Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity [PDF]
, 2023 Antibody–drug conjugates (ADCs) constitute a rapidly expanding category of biopharmaceuticals that are reshaping the landscape of targeted chemotherapy.
Jezabel Garcia-Parra +10 more
core +1 more source