Results 41 to 50 of about 2,528,348 (198)

Versatile and rapid microfluidics-assisted antibody discovery

mAbs, 2021
Recent years have seen unparalleled development of microfluidic applications for antibody discovery in both academic and pharmaceutical research. Microfluidics can support native chain-paired library generation as well as direct screening of antibody ...
Ramona Gaa, Emmanuel Menang-Ndi, Shruti Pratapa, Christine Nguyen, Satyendra Kumar, Achim Doerner   +5 more
doaj   +1 more source

Antibody-Catalyzed Enantioselective Robinson Annulation [PDF]

, 2016
Antibody-Catalyzed Enantioselective Robinson ...
Guofu Zhong (1508497), Samuel Danishefsky (3001173), Richard A. Lerner (363483), Torsten Hoffmann (1912042), Carlos F. Barbas (19478)   +4 more
core   +1 more source

Early Diagnosis and Successful Treatment of Acute Antibody-Mediated Rejection of a Renal Transplant [PDF]

, 2011
Antibody-mediated rejection is a delicate situation. it rarely occurs but when it does, it usually results in graft dysfunction and frequently, graft loss.
YANG, YA-WEN;LIN, WEI-CHOU;WU, MING-SHIOU;LEE, PO-HUANG;TSAI, MENG-KUN, 楊雅雯;林維洲;吳明修;李伯皇;蔡孟昆   +1 more
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ipRGCs Sensitive Blue Light Exposure Promotes the Robustness of Circadian and Neural Stem Cells in Sleep Deprived Conditions

Stem Cells International
Circadian rhythm abnormalities due to sleep deprivation (SD) may promote the development of emotional and cognitive disorders. Though light therapies have been employed to treat circadian disorders, the exact treatments and their underlying biology are ...
Zhaoting Bu, Xiaotong Li, Jinyu Shi, Qiaozhen Qin, Heyang Zhang, Yuanrong Qiu, Lingyu Zhang, Yifei Tan, Hanping Shi, Xiaoxia Jiang   +9 more
doaj   +1 more source

A novel one-step approach for the construction of yeast surface display Fab antibody libraries

Microbial Cell Factories, 2018
Background Yeast surface display (YSD) has proven to be a versatile platform technology for antibody discovery. However, the construction of antibody Fab libraries typically is a tedious three-step process that involves the generation of heavy chain as ...
Simon Rosowski, Stefan Becker, Lars Toleikis, Bernhard Valldorf, Julius Grzeschik, Deniz Demir, Iris Willenbücher, Ramona Gaa, Harald Kolmar, Stefan Zielonka, Simon Krah   +10 more
doaj   +1 more source

Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice

Viruses, 2020
The genus Henipavirus (HNVs) includes two fatal viruses, namely Nipah virus (NiV) and Hendra virus (HeV). Since 1994, NiV and HeV have been endemic to the Asia–Pacific region and responsible for more than 600 cases of infections. Two emerging HNVs, Ghana
Yaohui Li, Ruihua Li, Meirong Wang, Yujiao Liu, Ying Yin, Xiaodong Zai, Xiaohong Song, Yi Chen, Junjie Xu, Wei Chen   +9 more
doaj   +1 more source

Development of antibodies against severe fever with thrombocytopenia syndrome virus nucleoprotein for diagnosis

Applied Microbiology and Biotechnology
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease caused by a novel Bandavirus in the family Phenuiviridae. The SFTS virus (SFTSV) is transmitted to various hosts, including humans, through tick bites, leading to ...
Eun-Mee Park, Seheon Kim, Seoyoen Lim, Parastou Rahimizadeh, Hyeyoon Jeon, Hyung Jin Lim, Sungjin Lee, Yong Bhum Song   +7 more
doaj   +1 more source

Development of a high yielding expression platform for the introduction of non-natural amino acids in protein sequences

mAbs, 2020
The ability to genetically encode non-natural amino acids (nnAAs) into proteins offers an expanded tool set for protein engineering. nnAAs containing unique functional moieties have enabled the study of post-translational modifications, protein ...
Gargi Roy, Jason Reier, Andrew Garcia, Tom Martin, Megan Rice, Jihong Wang, Meagan Prophet, Ronald Christie, William Dall’Acqua, Sanjeev Ahuja, Michael A Bowen, Marcello Marelli   +11 more
doaj   +1 more source

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Maruani, A, Caddick, S, Smith, ME, Chester, KA, Chudasama, V, Miranda, E   +5 more
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Engineering of the binding profile of a new class of antibody like proteins [PDF]

, 2022
reservedAfter a manual screening of antibody like protein candidates obtained from computational analysis, the most ranked candidate has been selected for engineering the binding-surface against a specific molecular ...
CARTURA, MATTEO
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