Results 81 to 90 of about 2,678,192 (313)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity

, 2023
Antibody–drug conjugates (ADCs) constitute a rapidly expanding category of biopharmaceuticals that are reshaping the landscape of targeted chemotherapy.
Jezabel Garcia-Parra, Lewis Webb Francis, Robert Steven Conlan, Deyarina Gonzalez, Emenike Kenechi Onyido, John Sinfield, Zoe Coombes, Anna Moberg, Nicole Williams, David James, Jenny Worthington   +10 more
core   +1 more source

A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer

Journal of Experimental & Clinical Cancer Research, 2020
Background Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy.
Yuexian Zhou, Huifang Zong, Lei Han, Yueqing Xie, Hua Jiang, John Gilly, Baohong Zhang, Huili Lu, Jie Chen, Rui Sun, Zhidi Pan, Jianwei Zhu   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A study of antibody secretion from hybridoma cells [PDF]

, 1988
The secretion of monoclonal antibody in both batch and continuous cultures was studied. It was found that when hybridoma cells were continuously cultivated in a simple lab scale fermenter, they secreted less antibody than cells grown in stationary ...
Holland, P.N.
core  

Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific.

, 2008
Naturally acquired antibody responses provide partial protection from clinical malaria, and blood-stage parasite vaccines under development aim to prime such responses. To investigate the determinants of antibody response longevity, immunoglobulin G (IgG)
Conway, David J, Samuel Dunyo, Tetteh, Kevin KA, Dunyo, Samuel, Lanar, David E, Akpogheneta, Onome J, Margaret Pinder, Duah, Nancy O, Pinder, Margaret, David E. Lanar, David J. Conway, Onome J. Akpogheneta, Nancy O. Duah, Kevin K. A. Tetteh   +13 more
core   +1 more source

Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort. [PDF]

, 2010
Information on the period during which infants lose their maternally derived antibodies to malaria and begin to acquire naturally their own immune responses against parasite antigens is crucial for understanding when malaria vaccines may be best ...
Duah, NO, D. J. C. MILES, Conway, DJ, N. O. DUAH, Whittle, HC, H. C. WHITTLE, D. J. CONWAY, Miles, DJC   +7 more
core   +1 more source

Tailored FcγR blockade enhances immune checkpoint therapy and overcomes resistance

Journal of Experimental & Clinical Cancer Research
Background Fc-gamma receptors (FcγRs) regulate IgG antibody activity, and Fc-engineering is a proven method to improve the efficacy of tumor-targeting antibodies.
Robert J. Oldham, Linda Mårtensson, Monika Semmrich, Niyaz Yoosuf, Petra Holmkvist, Lara V. Graham, Martin C. Taylor, Kirstie L. S. Cleary, Mona Yazdani, Josephine F. Buckingham, Ali Roghanian, Ingrid Karlsson, Stephen A. Beers, Ingrid Teige, Mark S. Cragg, Björn Frendéus   +15 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The effect of daily co-trimoxazole prophylaxis on natural development of antibody-mediated immunity against P. falciparum malaria infection in HIV-exposed uninfected Malawian children. [PDF]

, 2015
BACKGROUND AND OBJECTIVES: Co-trimoxazole prophylaxis, currently recommended in HIV-exposed, uninfected (HEU) children as protection against opportunistic infections, also has some anti-malarial efficacy.
Tom Hall (712080), Kamija S Phiri, Gondwe, Thandile, Jambo, Kondwani C, Tetteh, Kevin KA, Longwe, Herbert, Chris Drakeley (79962), Wilson L. Mandala (360369), Drakeley, Chris, Kevin K A Tetteh, Phiri, Kamija S, Chris Drakeley, Nyanyiwe Mbeye, Mandala, Wilson L, Nyanyiwe Mbeye (712078), Tom Hall, Kondwani C. Jambo (159487), Kevin K. A. Tetteh (122339), Wilson L Mandala, Thandile Gondwe (712079), Herbert Longwe (712077), Herbert Longwe, Thandile Gondwe, Mbeye, Nyanyiwe, Kamija S. Phiri (52377), Hall, Tom, Kondwani C Jambo   +26 more
core   +2 more sources