Sex Differences in Response to Viral Vector Vaccines-Implications for Future Vaccine Design. [PDF]
Immunol RevGrewe I, Zoran T, Addo MM.
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlating Stimulated Emission Depletion Microscopy With Fluorescence Lifetime Imaging Microscopy to Study the TIE2 Protein on Kidney Glomerular Podocytes. [PDF]
J Histochem CytochemDénes IA +5 more
europepmc +1 more source
Importance of Recrudescent Avian Infection in West Nile Virus Overwintering: Incomplete Antibody Neutralization of Virus Allows Infrequent Vector Infection [PDF]
, 2012 Sarah S. Wheeler +3 more
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Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
An integrated cell and medium engineering approach for production of a nanobody fusion in Saccharomyces cerevisiae. [PDF]
Appl Microbiol BiotechnolNiemelä LRK +4 more
europepmc +1 more source
Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation [PDF]
, 2018 Simone Beck +7 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Adjuvanted influenza vaccination increases pre-existing H5N1 cross-reactive antibodies - Code
Meyer, Benjamin +1 more
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