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Designing antibodies as therapeutics
Cell, 2022Antibody therapeutics are a large and rapidly expanding drug class providing major health benefits. We provide a snapshot of current antibody therapeutics including their formats, common targets, therapeutic areas, and routes of administration. Our focus is on selected emerging directions in antibody design where progress may provide a broad benefit ...
Paul J. Carter, Arvind Rajpal
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Designer and Catalytic Antibodies
New England Journal of Medicine, 1990A HUMAN being possesses on the order of 1 trillion (1012) B cells, capable of making more than 10 million different antibodies. Tapping this vast resource for clinical purposes is an important but technically challenging endeavor. The production of hybridomas makes it feasible to manufacture large quantities of monoclonal antibodies, and in principle ...
Jane F. Desforges +2 more
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Computational design of antibodies
Current Opinion in Structural Biology, 2018Antibody design aims to create new antibodies with biological activity that can be used in therapy and research. Traditional methods for antibody discovery, such as animal immunization and large-scale library screening, generate antibodies that bind to the target of interest, but do not necessarily have the desired functional effect.
Sharon, Fischman, Yanay, Ofran
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Nature Biotechnology, 1998
Monoclonal antibodies (Mabs) have long been considered a good class of natural drugs, both because they mimic their natural role in the body and because they have no inherent toxicity. Although rodent Mabs are readily generated, their widespread use as therapeutic agents has been hampered because they are recognized as foreign by the patient. Evidently,
T J, Vaughan, J K, Osbourn, P R, Tempest
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Monoclonal antibodies (Mabs) have long been considered a good class of natural drugs, both because they mimic their natural role in the body and because they have no inherent toxicity. Although rodent Mabs are readily generated, their widespread use as therapeutic agents has been hampered because they are recognized as foreign by the patient. Evidently,
T J, Vaughan, J K, Osbourn, P R, Tempest
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Phospho-specific antibodies by design
Nature Biotechnology, 2013Antibodies specific to phosphorylated peptides are readily generated through structure-based engineering and in vitro selection.
Oda Stoevesandt, Michael J Taussig
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Designing Two-In-One Antibodies
Immunotherapy, 2009Evaluation of: Bostrom J, Shang-Fan Y, Kan D et al.: Variants of the antibody Herceptin that interact with HER2 and VEGF at the antigen binding site. Science 323, 1610-1614 (2009). The longstanding held notion that one antibody equals one antigen and, hence, one function has been challenged in recent years.
Ignacio Garcia, Valladares +1 more
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Designing antibodies for oncology
Cancer and Metastasis Reviews, 2005The past five years have witnessed the emergence of monoclonal antibodies as important therapeutics for cancer treatment. Lower toxicity for antibodies versus small molecules, the potential for increased efficacy by conjugation to radioisotopes and cellular toxins, or the ability to exploit immune cell functions have led to clinical performances on par
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Structure-Guided Design of Antibodies
Current Computer Aided-Drug Design, 2010Monoclonal antibodies capable of recognizing antigens with high affinity and specificity represent a wellestablished class of biological agents. Since the development of hybridoma technology in 1975, advances in recombinant DNA technologies and computational and biophysical methods have allowed us to develop a better understanding of the relationships ...
Justin A, Caravella +3 more
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