Results 181 to 190 of about 10,558,921 (293)

Observation of redistribution for local conformational dynamics in cross-reactive antibody design. [PDF]

J Biochem
Yasuda Y, Nagatoishi S, Sasaki J, Matsunaga R, Kuroda D, Hashiguchi T, Tsumoto K.   +6 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Antibody Drug Design

CD ComputaBio is a leading global company providing compelling and novel solutions in computer-aided drug design. We prioritize the integration of our advanced computational capabilities with our extensive expertise in antibody drug design to offer a range of services.
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

GeoGAD: geometry-aware antibody design framework for complementarity-determining region precision engineering. [PDF]

Bioinformatics
Wei S, Zhang J, Chen Y, Tang C, Tan J.
europepmc   +1 more source

Specific epitopes form extensive hydrogen-bonding networks to ensure efficient antibody binding of SARS-CoV-2: Implications for advanced antibody design. [PDF]

Comput Struct Biotechnol J, 2021
Wang D, Ge Y, Zhong B, Liu D.
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Design Research and Public Policy: Current Practice Working to Intersect with Government

, 2014
Design research is an academic and practical field of study that seeks to explore the ways in which design in any discipline area is produced, understood, and used.
Parliamentary Design and Innovation Group, All Party
core  

Ab-SELDON: Leveraging Diversity Data for an Efficient Automated Computational Pipeline for Antibody Design. [PDF]

J Chem Inf Model
Sampaio JV, Costa AHS, Albuquerque AO, Souza JS, Almeida DS, Gaieta EM, Almeida MV, Sartori GR, Silva JHM.   +8 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source