Infectious bursal disease virus suppresses humoral immunity via blocking antibody affinity maturation in chickens [PDF]
iScienceSummary: Blockade of antibody affinity maturation causes vaccination failure, yet whether pathogens exploit this process for immunosuppression remains poorly understood. Infectious bursal disease virus (IBDV) causes immunosuppression in chickens, but its
Yuxin Guo +7 more
doaj +2 more sources
Nucleotide context models outperform protein language models for predicting antibody affinity maturation. [PDF]
PLoS Computational BiologyAntibodies play a crucial role in adaptive immunity. They develop as B cell receptors (BCRs): membrane-bound forms of antibodies that are expressed on the surfaces of B cells.
Mackenzie M Johnson +8 more
doaj +2 more sources
Local and Global Rigidification Upon Antibody Affinity Maturation
Frontiers in Molecular Biosciences, 2020 During the affinity maturation process the immune system produces antibodies with higher specificity and activity through various rounds of somatic hypermutations in response to an antigen.
Klaus Liedl +2 more
exaly +3 more sources
Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution [PDF]
Cell ReportsSummary: A key goal of vaccinology is to train the immune system to combat current pathogens while preparing it for future variants. Here, we investigate how Wuhan strain severe acute respiratory syndrome coronavirus 2 mRNA vaccination generates ...
John Dingus +11 more
doaj +2 more sources
Antibody Affinity Maturation in Fishes—Our Current Understanding
Biology, 2015 It has long been believed that fish lack antibody affinity maturation, in part because they were thought to lack germinal centers. Recent research done on sharks and bony fishes indicates that these early vertebrates are able to affinity mature their ...
Brad Magor
exaly +3 more sources
High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization [PDF]
iScienceSummary: Antigen-specific antibody infusion is known to enhance or suppress germinal center (GC) responses depending on the affinity of the infusion. We hypothesized that infusing monoclonal antibodies (mAbs) of escalating affinity during an immunization
Peter Thomas +14 more
doaj +2 more sources
Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing
Frontiers in Immunology, 2018 Affinity maturation is the process whereby the immune system generates antibodies of higher affinities during a response to antigen. It is unique in being the only evolutionary mechanism known to operate on a molecule in an organism’s own body ...
Arjun K Mishra +2 more
exaly +3 more sources
CFP1 promotes germinal center affinity maturation and restrains memory B cell differentiation through H3K4me3 modulation [PDF]
Nature CommunicationsAffinity maturation and differentiation of B cells in the germinal center (GC) are tightly controlled by epigenetically regulated transcription programs, but the underlying mechanisms are only partially understood.
Yanan Zhao +7 more
doaj +2 more sources
Pretrainable geometric graph neural network for antibody affinity maturation [PDF]
Nature CommunicationsIncreasing the binding affinity of an antibody to its target antigen is a crucial task in antibody therapeutics development. This paper presents a pretrainable geometric graph neural network, GearBind, and explores its potential in in silico affinity ...
Huiyu Cai +8 more
doaj +2 more sources
Adapting Neutralizing Antibodies to Viral Variants by Structure‐Guided Affinity Maturation Using Phage Display Technology [PDF]
Global Challenges, 2023 Neutralizing monoclonal antibodies have achieved great efficacy and safety for the treatment of numerous infectious diseases. However, their neutralization potency is often rapidly lost when the target antigen mutates. Instead of isolating new antibodies
Frederik Peissert +15 more
doaj +2 more sources