Results 11 to 20 of about 158,250 (254)
Affinity Maturation of a Fentanyl Aptamer by Motif-SELEX [PDF]
JACS AuOligonucleotide-based aptamers are increasingly being used as recognition elements in biosensors to detect analytes relevant to diverse applications including medical diagnostics and therapeutic drug monitoring. Nevertheless, the utility of aptamers is often hindered by their insufficient target-binding affinity.
Obtin Alkhamis +6 more
doaj +4 more sources
Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation
Frontiers in Immunology, 2014 Affinity maturation of the antibody response is a fundamental process in adaptive immunity during which B cells activated by infection or vaccination undergo rapid proliferation accompanied by the acquisition of point mutations in their rearranged ...
Christopher W Woods +2 more
exaly +3 more sources
In Vitro Affinity Maturation of Nanobodies against Mpox Virus A29 Protein Based on Computer-Aided Design [PDF]
Molecules, 2023 , Qingqiang Xu, Zhipeng Pei
exaly +2 more sources
Nature Communications, 2023 Antibody affinity maturation enables adaptive immune responses to a wide range of pathogens. In some individuals broadly neutralizing antibodies develop to recognize rapidly mutating pathogens with extensive sequence diversity.
Rory Henderson +13 more
doaj +1 more source
AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans. [PDF]
PLoS Pathogens, 2012 The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09
Surender Khurana +3 more
doaj +1 more source
Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers. [PDF]
PLoS ONE, 2015 Upon natural infection with pathogens or vaccination, antibodies are produced by a process called affinity maturation. As affinity maturation ensues, average affinity values between an antibody and ligand increase with time.
Myungsun Kang +4 more
doaj +1 more source
Frontiers in Immunology, 2023 A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg +5 more
doaj +1 more source
IgM Accelerates Affinity Maturation [PDF]
Scandinavian Journal of Immunology, 2005 AbstractSecreted IgM is a potent adjuvant that concentrates antigen into secondary lymphoid organs and initiates antibody responses, germinal centre formation and is crucial in resolving infections. The current studies investigated the influence of specific IgM on both the quantity and quality of antibody produced in response to T‐dependent and T ...
R B, Corley +2 more
openaire +2 more sources
In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation [PDF]
mAbs, 2014 Antibodies isolated from human donors are increasingly being developed for anti-infective therapeutics. These antibodies undergo affinity maturation in vivo, minimizing the need for engineering of therapeutic leads for affinity. However, the affinities required for some therapeutic applications may be higher than the affinities of the leads obtained ...
Bing, Li +8 more
openaire +2 more sources
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies
EMBO Molecular Medicine, 2023 Human monoclonal antibodies (mAbs) against the central repeat and junction domain of Plasmodium falciparum circumsporozoite protein (PfCSP) have been studied extensively to guide malaria vaccine design compared to antibodies against the PfCSP C terminus.
Opeyemi Ernest Oludada +12 more
doaj +1 more source