Results 31 to 40 of about 158,250 (254)
Fast-tracking antibody maturation using a B cell-based display system
mAbs, 2022 Affinity maturation, an essential component of antibody engineering, is crucial for developing therapeutic antibodies. Cell display system coupled with somatic hypermutation (SHM) initiated by activation-induced cytidine deaminase (AID) is a commonly ...
Hitomi Masuda +9 more
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Cell Reports, 2018 Summary: Antibody affinity maturation, which is an antigen-based selection process for B cells, occurs in germinal centers (GCs). GCB cells must efficiently recognize, acquire, and present antigens from follicular dendritic cells (FDCs) to receive ...
Jingjing Chen +12 more
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iScience, 2022 Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...
Fangzhu Zhao +22 more
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A molecular theory of germinal center B cell selection and division
Cell Reports, 2021 Summary: The selection of B cells (BCs) in germinal centers (GCs) is pivotal to the generation of high-affinity antibodies and memory BCs, but it lacks global understanding.
Michael Meyer-Hermann
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Antibody Engineering Towards Enhancement of Spike Protein SARS-COV-2 -m396 Binding Affinity
Regeneration, Reconstruction & Restoration, 2021 Introduction: The SARS-COV-2 is a non-segmented positive-sense RNA virus that belongs to the genus Beta Coronavirus. The envelope-anchored trimeric spike protein on the virus surface is considered to be the key protein for the viral entry into the host ...
Fateme Sefid +3 more
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mBio, 2015 Antibody (Ab) affinity maturation enables an individual to maintain immunity to an increasing number of pathogens within the limits of a total Ig production threshold.
Gregory M. Frank +11 more
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Understanding and Modulating Antibody Fine Specificity: Lessons from Combinatorial Biology
Antibodies, 2022 Combinatorial biology methods such as phage and yeast display, suitable for the generation and screening of huge numbers of protein fragments and mutated variants, have been useful when dissecting the molecular details of the interactions between ...
Gertrudis Rojas
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Antibodies, 2022 Yeast surface display techniques have been increasingly employed as a tool for both the discovery and affinity maturation of antibodies. In this study, we describe the use of yeast surface display for the selection and affinity maturation of antibodies ...
Bhupal Ban +2 more
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A Sensitivity Analysis Comparison of Three Models for the Dynamics of Germinal Centers
Frontiers in Immunology, 2019 Germinal centers (GCs) are transient anatomical microenvironments where antibody affinity maturation and memory B cells generation takes place. In the past, models of Germinal Center (GC) dynamics have focused on understanding antibody affinity ...
Jose Faro +5 more
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In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom
mAbs, 2022 The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which is predominantly derived from long-chain α-neurotoxins.
Line Ledsgaard +19 more
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