Results 111 to 120 of about 1,117,835 (218)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A rapid immunochromatographic test for antibody detection as a new tool for monitoring malaria caused by Plasmodium vivax. [PDF]

PLoS Negl Trop Dis
Sampaio JR, Coelho FF, Soares IDS, Oliveira JKA, Gazzinelli-Guimarães AC, Carvalho AF, Valiate BVS, Costa CM, Junqueira C, Silva AMV, Oliveira-Silva M, Pereira DB, de Pina-Costa A, Siqueira AM, Castro MC, Souza RP, Antonelli LRDV, Fernandes APSM, Gazzinelli RT, Almeida GG.   +19 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Development of a Colloidal Gold Immunochromatographic Test Strip for PPRV Antibody Detection Based on Antigenic Epitope-Derived Recombinant Protein. [PDF]

Animals (Basel)
Wang S, Han C, Sun C, Zhang D, Liu Y.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

MARPLE: A Proximity-Triggered CRISPR-Cas13 Platform for Ultrasensitive Antibody Detection. [PDF]

Adv Sci (Weinh)
Spezzani E, Capelli L, Di Lena D, Chamorro-Garcia A, Ippodrino R, Porchetta A, Bertucci A.   +6 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Comparison of Cobas Plasma Separation Cards and Whatman filter paper cards versus conventional serum samples for anti-Trypansoma cruzi antibody detection. [PDF]

PLoS Negl Trop Dis
Silgado A, Mediavilla A, Martínez-Vallejo P, Rubio-Maturana C, Goterris L, Bosch-Nicolau P, Oliveira-Souto I, Serre-Delcor N, Molina I, Sulleiro E.   +9 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Comparison of the Prognostic Value of Three Different Single HLA Based Antibody Detection Assays. [PDF]

HLA
Heinemann FM, Hallensleben M, Althaus K, Budde K, Einecke G, Eisenberger U, Ender A, Feldkamp T, Grahammer F, Guthoff M, Holzmann-Littig C, Hugo C, Kauke T, Kemmner S, Koch M, Lachmann N, Lindemann M, Morath C, Nitschke M, Renders L, Scherer S, Schlaf G, Stumpf J, Schwenger V, Sommer F, Spriewald BM, Süsal C, Verboom M, Zecher D, Ziemann M.   +29 more
europepmc   +1 more source