Results 31 to 40 of about 1,117,835 (218)

A preliminary investigation of exposure to rabies virus in selected wildlife in the Kruger National Park, South Africa

Koedoe: African Protected Area Conservation and Science, 2021
Rabies is a zoonotic disease caused by members of the genus Lyssavirus and causes fatal encephalitis in warm-blooded vertebrates. Rabies has been previously confirmed in domestic dog populations in close proximity to the Kruger National Park (KNP) and ...
Leana Rossouw, Carin Boshoff, Claude Sabeta, Johann Kotzé   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Development and evaluation of an in-house ELISA based on autochthonous antigens for detecting IgG anti-Helicobacter pylori in Cuban adults

Exploration of Digestive Diseases
Aim: This study aimed to develop and evaluate an in-house enzyme-linked immunosorbent assay (ELISA) based on autochthonous antigens to detect immunoglobulin G (IgG) antibodies against Helicobacter pylori (H. pylori) in adult sera.
Rosabel Corrales, Rosabel Falcón, Susana Vázquez, Onelkis Feliciano, Reinaldo Mederos, Amílcar Duquesne, Oderay Gutierrez, Rafael Llanes   +7 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Comparative assessment of immunochromatographic test kits using low-molecular-weight antigens from cyst fluids of two different genotypes of Taenia solium for serodiagnosis of human cysticercosis

Parasite
Human cysticercosis is a serious zoonosis caused by infection with larvae (cysticerci) of the pork tapeworm, Taenia solium. Infection can involve the nervous system, causing chronic headache and intracranial hypertension, focal neurological deficits ...
Sadaow Lakkhana, Janwan Penchom, Boonroumkaew Patcharaporn, Rodpai Rutchanee, Sanpool Oranuch, Thanchomnang Tongjit, Sato Marcello Otake, Intapan Pewpan M., Yamasaki Hiroshi, Sako Yasuhito, Wandra Toni, Swastika Kadek, Maleewong Wanchai   +12 more
doaj   +1 more source

Detection of Antibodies against Mycobacterium bovis in Oral Fluid from Eurasian Wild Boar

Pathogens, 2020
The presence of Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex (MTC) is a main concern in wildlife populations such as the Eurasian wild boar (Sus scrofa).
Jose A. Barasona, Sandra Barroso-Arévalo, Belén Rivera, Christian Gortázar, Jose M. Sánchez-Vizcaíno   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source