Results 121 to 130 of about 256,130 (281)

1294 Engineering a T cell receptor (TCR) into an antibody drug format provides a novel approach to half-life extended T cell engagers targeting PRAME A2 and PRAME A24 [PDF]

Hemza Ghadbane, Dominic Hine, Patricia Cain, Louise Holland, Eleanor A. L. Bagg, Jana Rundle, Juan Bolivar, Xiaoyan Pan, Maria Busz, Samantha Drennan, David N. Cook, Sue Wells, Wilawan Bunjobpol, M. E. Marongiu, Mathew Veal, Samhita Rao, Maria Kokolaki, Alex Stephens, Daniel Burns, Amalia Martinez, Dzmitry G. Batrakou, Sophie Johnson, Oleksandr Dudchenko, Samuel R. Ward, Simon W. Wright, On Kan, Marjorie B. Lees, Graham S. Ogg, Nathaniel J. Davies, Thomas L. Andresen, Sarah Leonard   +30 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Monoclonal Antibody Engineering and Design to Modulate FcRn Activities: A Comprehensive Review. [PDF]

Int J Mol Sci, 2022
Ramdani Y, Lamamy J, Watier H, Gouilleux-Gruart V.   +3 more
europepmc   +1 more source

Engineering host cell lines to reduce terminal sialylation of secreted antibodies [PDF]

, 2010
Michael Naso, Susan H. Tam, Bernard J. Scallon, T. Shantha Raju   +3 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

In silico antibody engineering for SARS-CoV-2 detection. [PDF]

Comput Struct Biotechnol J, 2021
Martí D, Martín-Martínez E, Torras J, Bertran O, Turon P, Alemán C.   +5 more
europepmc   +1 more source

Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions

BMC Cancer
Background Serine/glycine are critical for the growth and survival of cancer cells. Some cancer cells are more dependent on exogenous serine/glycine than endogenously synthesized serine/glycine.
Huijuan Wang, Mengzhen Fan, Sichang Liu, Mengjiao Qu, Xin Hou, Junqing Hou, Yanxin Xu, Xiaodi Shang, Chen Liu, Mingxia He, Jianzheng Gao, Jingying Chen, Xia Li   +12 more
doaj   +1 more source

Novel envelope protein time-resolved fluoroimmunoassay as an alternative in vitro potency assay for quality control of inactivated Japanese encephalitis virus vaccine

Heliyon
Japanese encephalitis (JE) vaccination is the most effective way to prevent JE. Plaque reduction neutralization test (PRNT) as the standard method for potency testing for inactivated JE vaccine could not provide the exact potency value.
Zhaoyue Li, Hui Zhao, Xuzhe Gao, Feifei Sun, Shiyuan Liu, Zhigao Zhang, Xiangming Zhai, Yue Cao, Yingsong Wu, Guanfeng Lin   +9 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Strategies to mitigate the on- and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective. [PDF]

Antib Ther, 2022
Li M, Mei S, Yang Y, Shen Y, Chen L.
europepmc   +1 more source