Results 121 to 130 of about 411,227 (332)

Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates. [PDF]

, 2019
Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy for treating metastatic tumors ...
Chen, Irvin SY, Guan, Jiaoqiong, Guo, Qi, He, Zhanlong, Kamata, Masakazu, Kranz, Emiko, Lee, YooJin, Lu, Yunfeng, Luo, Yun, Qin, Meng, Sun, Guibo, Sun, Xiaobo, Vinters, Harry V, Wang, Lan, Wen, Jing, Williams, Christopher K, Wu, Di, Xie, Yiming, Xu, Duo   +18 more
core   +1 more source

709. Engineering Human T Cells To Express scFv Antibody Fusion Proteins [PDF]

, 2003

openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Comparative analysis of neutralization assays performed using live SARS-CoV-2 virus and pseudovirus to assess immunogenicity of a bivalent SARS-CoV-2 protein vaccine in humans

Frontiers in Immunology
ObjectivesThe rapid emergence of SARS-CoV-2 prompted accelerated vaccine development, with neutralization assays serving as essential tools to evaluate vaccine-induced immune responses.MethodsA post-hoc analysis of a Phase I/II trial evaluated the ...
Cuige Gao, Jiang Yi, Adam Baidoo, Dongfang Liu, Jing Li, Dongyang Li, Jian Li, Qiang Zhou, Liangzhi Xie, Liangzhi Xie, Liangzhi Xie   +10 more
doaj   +1 more source

Simplifying complex antibody engineering using machine learning. [PDF]

Cell Syst, 2023
Makowski EK, Chen HT, Tessier PM.
europepmc   +1 more source

Antibody engineering [PDF]

Nature Biotechnology, 2020
openaire   +2 more sources

Antibody engineering: facing new challenges in cancer therapy [PDF]

, 2005
Laura Sanz, Ángel M. Cuesta, Marta Compte, Luís Álvarez-Vallina   +3 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Immunogenicity Assessment of a 14-Valent Human Papillomavirus Vaccine Candidate in Mice

Vaccines
Background: Cervical cancer ranks as the fourth most common cancer affecting women globally, with HPV as the primary etiology agent. Prophylactic HPV vaccines have substantially reduced the incidence of cervical cancer.
Lei Bei, Shuman Gao, Dandan Zhao, Yajuan Kou, Siyu Liang, Yurong Wu, Xiao Zhang, Dan Meng, Jianbo Lu, Chunxia Luo, Xuefeng Li, Yang Wang, Hongbin Qiu, Liangzhi Xie   +13 more
doaj   +1 more source

AI Models for Protein Design are Driving Antibody Engineering. [PDF]

Curr Opin Biomed Eng, 2023
Chungyoun M, Gray JJ.
europepmc   +1 more source