Results 141 to 150 of about 5,391,353 (307)

Engineering Vanderbilt; Vol. 51, No. 02, 2010

, 2010
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.* 2 * from the dean * 6 * cover story - The Infinite to the Finite: Vanderbilt Researchers Imagine the Future of Imaging Science and ...
Vanderbilt University. School of Engineering
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Unlocking the potential of agonist antibodies for treating cancer using antibody engineering. [PDF]

Trends Mol Med, 2023
Jhajj HS, Lwo TS, Yao EL, Tessier PM.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions

BMC Cancer
Background Serine/glycine are critical for the growth and survival of cancer cells. Some cancer cells are more dependent on exogenous serine/glycine than endogenously synthesized serine/glycine.
Huijuan Wang, Mengzhen Fan, Sichang Liu, Mengjiao Qu, Xin Hou, Junqing Hou, Yanxin Xu, Xiaodi Shang, Chen Liu, Mingxia He, Jianzheng Gao, Jingying Chen, Xia Li   +12 more
doaj   +1 more source

Monoclonal Antibody Engineering and Design to Modulate FcRn Activities: A Comprehensive Review. [PDF]

Int J Mol Sci, 2022
Ramdani Y, Lamamy J, Watier H, Gouilleux-Gruart V.   +3 more
europepmc   +1 more source

Engineering Vanderbilt; Vol. 51 No. 01, 2010

, 2010
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.Page 2 from the dean * Page 6 cover story From Startups to Success: VUSE Engineers Thrive as Entrepreneurs in Businesses Large ...
Vanderbilt University. School of Engineering
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Tissue‐specific targeting of the ARF6 signalling axis for type 2 diabetes and obesity: From mechanism to nanodelivery

Clinical and Translational Medicine
Disorders of glucose metabolism, particularly type 2 diabetes and obesity, remain major therapeutic challenges because they involve dysfunction across multiple tissues, including pancreatic β‐cells, peripheral insulin‐sensitive tissues, and immune cells.
Yangyang Wang, Yan He, Zhiming Xiu, Huiyan Wang   +3 more
doaj   +1 more source

In silico antibody engineering for SARS-CoV-2 detection. [PDF]

Comput Struct Biotechnol J, 2021
Martí D, Martín-Martínez E, Torras J, Bertran O, Turon P, Alemán C.   +5 more
europepmc   +1 more source