Results 151 to 160 of about 411,227 (332)

Engineering a Single-Chain Fv Antibody to αvβ6 Integrin Using the Specificity-Determining Loop of a Foot-and-Mouth Disease Virus [PDF]

, 2008
Heide Kogelberg, Berend Tolner, Gareth J. Thomas, Danielle Di Cara, Shane Minogue, Balasubramaniam Ramesh, Serena Sodha, D. Marsh, Mark W. Lowdell, Tim Meyer, Richard H. J. Beǵent, Ian R. Hart, John F. Marshall, Kerry Chester   +13 more
openalex   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Novel envelope protein time-resolved fluoroimmunoassay as an alternative in vitro potency assay for quality control of inactivated Japanese encephalitis virus vaccine

Heliyon
Japanese encephalitis (JE) vaccination is the most effective way to prevent JE. Plaque reduction neutralization test (PRNT) as the standard method for potency testing for inactivated JE vaccine could not provide the exact potency value.
Zhaoyue Li, Hui Zhao, Xuzhe Gao, Feifei Sun, Shiyuan Liu, Zhigao Zhang, Xiangming Zhai, Yue Cao, Yingsong Wu, Guanfeng Lin   +9 more
doaj   +1 more source

In silico antibody engineering for SARS-CoV-2 detection. [PDF]

Comput Struct Biotechnol J, 2021
Martí D, Martín-Martínez E, Torras J, Bertran O, Turon P, Alemán C.   +5 more
europepmc   +1 more source

Antibody molecular engineering and gene therapy for cancer.

, 1996
Y Hinoda, Kenichi Imai
openalex   +2 more sources

Toward chaperone‐assisted crystallography: Protein engineering enhancement of crystal packing and X‐ray phasing capabilities of a camelid single‐domain antibody (V_HH) scaffold [PDF]

, 2008
Valentina Tereshko, Serdar Uysal, Akiko Koide, Katrina Margalef, Shohei Koide, Anthony A. Kossiakoff   +5 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions

BMC Cancer
Background Serine/glycine are critical for the growth and survival of cancer cells. Some cancer cells are more dependent on exogenous serine/glycine than endogenously synthesized serine/glycine.
Huijuan Wang, Mengzhen Fan, Sichang Liu, Mengjiao Qu, Xin Hou, Junqing Hou, Yanxin Xu, Xiaodi Shang, Chen Liu, Mingxia He, Jianzheng Gao, Jingying Chen, Xia Li   +12 more
doaj   +1 more source

Strategies to mitigate the on- and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective. [PDF]

Antib Ther, 2022
Li M, Mei S, Yang Y, Shen Y, Chen L.
europepmc   +1 more source

Antibody Engineering Protocols

, 1995
Sudhir Paul
openalex   +1 more source