Results 161 to 170 of about 256,130 (281)

hAb-Convergent: an antibody rearrangement analysis system for therapeutic antibody engineering based on convergent evolution. [PDF]

Nucleic Acids Res
Wang J, Ge X, Sun Q, Chen M, Qin S, Liu D, Deng T, Ma J, Hu S, Jin R, Tong Z, Wu L.   +11 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Targeting acute myeloid leukemia through antibody engineering: innovations in immunotherapy and combination regimens. [PDF]

Clin Exp Med
Soleimani Samarkhazan H, Noormohamadi H, Shafiei FS, Taghinejad Z, Maleknia M, Raoufi A, Nouri S, Mohammadi MH.   +7 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Structure-guided bispecific antibody engineering confers broad protection against KP.3.1.1 and sarbecoviruses. [PDF]

iScience
Ma Y, Liu Q, Rehati P, Zhang Z, Wang Y, Liu Z, Chen J, Bai X, Hao A, Wang Y, Wen Y, Chen Z, Lu L, Zhao J, Wu F, Sun L, Huang J.   +16 more
europepmc   +1 more source

mmCSM-AB: guiding rational antibody engineering through multiple point mutations. [PDF]

Nucleic Acids Res, 2020
Myung Y, Pires DEV, Ascher DB.
europepmc   +1 more source

Engineering of Escherichia coli β‐galactosidase for solvent display of a functional scFv antibody fragment [PDF]

, 2002
Pilar Alcalá, Neus Ferrer‐Miralles, Antonio Villaverde   +2 more
openalex   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Antibody numbering schemes: advances, comparisons and tools for antibody engineering. [PDF]

Protein Eng Des Sel
Zhu Z, Ashrafian H, Tabrizi NM, Matas E, Girard L, Ma H, Nice EC.   +6 more
europepmc   +1 more source

Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy [PDF]

, 2017
Yusuke Mimura, Toshihiko Katoh, Radka Saldova, Róisín O’Flaherty, Tomonori Izumi, Yuka Mimura‐Kimura, Toshiaki Utsunomiya, Yoichi Mizukami, Kenji Yamamoto, Tsuneo Matsumoto, Pauline M. Rudd   +10 more
openalex   +1 more source