Results 271 to 280 of about 4,368,554 (323)
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Biotechnology and Bioprocess Engineering, 2002
Monoclonal antibodies (Mabs) have been used as diagnostic and analytical reagents since hybridoma technology was invented in 1975. In recent years, antibodies have become increasingly accepted as therapeutics for human diseases, particularly for cancer, viral infection and autoimmune disorders.
Hyo Jeong Hong, Sun Taek Kim
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Monoclonal antibodies (Mabs) have been used as diagnostic and analytical reagents since hybridoma technology was invented in 1975. In recent years, antibodies have become increasingly accepted as therapeutics for human diseases, particularly for cancer, viral infection and autoimmune disorders.
Hyo Jeong Hong, Sun Taek Kim
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Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1989
The antibody molecule is a therapeutic agent, designed by nature to bind to a wide range of antigen molecules and to trigger effector functions, such as complement lysis and cell-mediated killing. The genes encoding antibodies can be manipulated in vitro , allowing the binding sites for antigen and effector ...
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The antibody molecule is a therapeutic agent, designed by nature to bind to a wide range of antigen molecules and to trigger effector functions, such as complement lysis and cell-mediated killing. The genes encoding antibodies can be manipulated in vitro , allowing the binding sites for antigen and effector ...
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Engineering Antibody Molecules
2000Advances in PCR techniques and the increase of the antibody V region sequences in the database have boosted developments in the field of antibody engineering. The V region genes can be amplified from hybridomas (1), preimmunized donors (2), naive donors (3), or from the cells expressing antibodies.
R, Verma, E, Boleti
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Recent Developments Toward Antibody Engineering and Affinity Maturation.
Protein Peptide Letters, 2018BACKGROUND Monoclonal antibodies have been proven to deliver significant contribution in health industry for the development of both therapeutics and diagnostics.
A. Rathore, A. Sarker, R. Gupta
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Antibody engineering to improve manufacturability.
Protein Expression and Purification, 2018Expression variation among antibodies produced by stably transfected Chinese Hamster Ovary (CHO) cells is well established. While developing CHO-K1 cell lines, we encountered a human monoclonal antibody, mAb B-c, with severe manufacturability issues ...
S. Wijesuriya +8 more
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1996
Abstract Recombinant DNA techniques have revolutionized the isolation and production of antibodies in recent years. This has resulted in rapid changes in how to handle antibodies for research. This new Practical Approach volume responds to this change by assembling, in one volume, protocols which allow the researcher to isolate a new ...
PAUL R. HINTON, BOB SHOPES
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Abstract Recombinant DNA techniques have revolutionized the isolation and production of antibodies in recent years. This has resulted in rapid changes in how to handle antibodies for research. This new Practical Approach volume responds to this change by assembling, in one volume, protocols which allow the researcher to isolate a new ...
PAUL R. HINTON, BOB SHOPES
+4 more sources
Engineering monoclonal antibodies
Nature, 1989Efforts to alter the mAb component of pharmaceuticals have focused on making them more human-lIke and smaller. Ultimately, the smallest molecular recognition unit derived from antibodies may be a single complementarity region.
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Methods, 2019
The antibody drug market is rapidly expanding, and various antibody engineering technologies are being developed to create antibodies that can provide better benefit to patients.
Hirotake Shiraiwa +19 more
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The antibody drug market is rapidly expanding, and various antibody engineering technologies are being developed to create antibodies that can provide better benefit to patients.
Hirotake Shiraiwa +19 more
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Genetically Engineered Antibody Molecules
1989Publisher Summary The availability of monoclonally derived hybridoma antibodies provided an infinite supply of homogeneous reagents so that laboratories around the world could use standardized procedures. However, some limitations persisted. One approach to producing hybridoma antibodies with more desirable biological effector functions or antigen ...
S L, Morrison, V T, Oi
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