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Antibody engineering, a strategy for the development of monoclonal antibodies
Antonie van Leeuwenhoek, 1984Antibody engineering is the selection process enabling the isolation of hybridoma clones, each of which produces an antibody with predefined qualities. The state of the art of hybridoma technology is reviewed with emphasis on the results obtained by antibody engineering in our laboratories for the development of monoclonal antibodies for specific use ...
E. H. Houwink, O. T. Schönherr
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Engineering Antibody Molecules
2000Advances in PCR techniques and the increase of the antibody V region sequences in the database have boosted developments in the field of antibody engineering. The V region genes can be amplified from hybridomas (1), preimmunized donors (2), naive donors (3), or from the cells expressing antibodies.
Ekaterini Boleti, Rakesh Verma
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Engineering Antibodies for Therapy
Current Pharmaceutical Biotechnology, 2002With eleven therapeutic antibodies approved worldwide and many more in clinical trials, research on antibody engineering has continued to escalate and expand. This review covers recent progress in generation of antibodies by ex vivo methods, systems for screening these, and the quest for higher affinity, more stable, optimally biodistributed antibody ...
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Engineering monoclonal antibodies
Nature, 1989Efforts to alter the mAb component of pharmaceuticals have focused on making them more human-lIke and smaller. Ultimately, the smallest molecular recognition unit derived from antibodies may be a single complementarity region.
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Protein Engineering of Antibodies
Critical Reviews in Biotechnology, 1992This article reviews the technical advances in antibody engineering and the clinical applications of these molecules. Recombinant DNA technology facilitates the construction and expression of engineered antibodies. These novel molecules are designed to meet specific applications.
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Antibody engineering for therapeutics
Current Opinion in Structural Biology, 2003With the acceptance of antibodies as therapeutics, a diversity of engineered antibody forms have been created to improve their efficacy, including enhancing the effector functions of full-length antibodies, delivering toxins to kill cells or cytokines in order to stimulate the immune system, and bispecific antibodies to target multiple receptors. After
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Increasing stability of antibody via antibody engineering: Stability engineering on an anti-hVEGF
Proteins: Structure, Function, and Bioinformatics, 2014Antibody stability is very important for expression, activity, specificity, and storage. This knowledge of antibody structure has made it possible for a computer-aided molecule design to be used to optimize and increase antibody stability. Many computational methods have been built based on knowledge or structure, however, a good integrated engineering
Zeng Dadi +7 more
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Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering
Drug Metabolism and Pharmacokinetics, 2019Monoclonal antibodies (mAbs) have become an important therapeutic option for several diseases. Since several mAbs have shown promising efficacy in clinic, the competition to develop mAbs has become severe. In efforts to gain a competitive advantage over other mAbs and provide significant benefits to patients, innovations in antibody engineering have ...
Tomoyuki Igawa +2 more
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Engineering Antibodies for Biosensor Technologies
2005Publisher Summary The emphasis of this chapter is directed towards the progress made using genetically engineered antibodies that could provide solutions to many of the problems currently associated with the use of conventional antibodies in biosensor systems.
Carl Nicholas Mayers +3 more
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Current Opinion in Structural Biology, 1993
Abstract The most recent developments in manipulation and selection of antibody genes indicate that the next generation of antibody-based products, particularly those destined for human therapy, could be created entirely in vitro.
Kevin Stuart Johnson +1 more
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Abstract The most recent developments in manipulation and selection of antibody genes indicate that the next generation of antibody-based products, particularly those destined for human therapy, could be created entirely in vitro.
Kevin Stuart Johnson +1 more
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