Results 291 to 300 of about 1,535,680 (331)
Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin +10 more
wiley +1 more source
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Antibody Formation in the Rat [PDF]
The Journal of Immunology, 1962 Summary The role of a) dose of antigen, b) the route of its injection, and c) presence or absence of the spleen in the primary and secondary agglutinin response of the rat have been studied using purified particulate flagella from Salmonella typhosa as antigen.
Frank W Fitch, James Winebright
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Science, 1963
The production of agglutinins to Salmonella typhi was studied in the opossum embryo in the period immediately before and after the development of thymic and lymph node lymphoid tissue. Antibody was found only in embryos older than 8 days which corresponds to an 8- to 10-week human embryo in terms of organogenesis ...
Mariano F. La Via +2 more
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The production of agglutinins to Salmonella typhi was studied in the opossum embryo in the period immediately before and after the development of thymic and lymph node lymphoid tissue. Antibody was found only in embryos older than 8 days which corresponds to an 8- to 10-week human embryo in terms of organogenesis ...
Mariano F. La Via +2 more
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Structure and Formation of Antibodies [PDF]
, 1969 Antibodies are proteins which are produced in vertebrates after stimulation with an antigen. They are specifically directed against the antigen which has caused their production.
Suter L +7 more
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Archives of Pediatrics & Adolescent Medicine, 1961
Until 15 to 20 years ago, immunologists believed that the ability of the young human infant to produce antibodies was extremely poor. Even though this ability gradually increased with age, it was not considered to reach a significant capacity until after several months of life. Investigations during the past 2 decades, however, have thrown new light on
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Until 15 to 20 years ago, immunologists believed that the ability of the young human infant to produce antibodies was extremely poor. Even though this ability gradually increased with age, it was not considered to reach a significant capacity until after several months of life. Investigations during the past 2 decades, however, have thrown new light on
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Cytokinetics of antibody formation
Journal of Cellular Physiology, 1966The mediastinal nodes of untreated rats contain medullary cords populated by variously matured plasmocytes, classified into large, medium, and small on the basis of nuclear diameters. Since hemocytopoietic cells proliferate while maturing and since proliferation yields progressively greater numbers of mitoses, it follows that the order of mitotic ...
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Nature, 1966
Molecular and Cellular Basis of Antibody Formation Edited by J. Sterzl, with the co-workers of the Immunological Department. (Proceedings of a Symposium held in Prague on June 1–5, 1964.) Pp. 683. (Prague: Publishing House of the Czechoslovak Academy of Sciences, 1965.) 82 Kcs.
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Molecular and Cellular Basis of Antibody Formation Edited by J. Sterzl, with the co-workers of the Immunological Department. (Proceedings of a Symposium held in Prague on June 1–5, 1964.) Pp. 683. (Prague: Publishing House of the Czechoslovak Academy of Sciences, 1965.) 82 Kcs.
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Reaginic Antibody Formation in the Mouse
The Journal of Immunology, 1972Abstract DBA/1 mice were immunized by an intraperitoneal injection of 0.2 to 1.0 µg of ovalbumin precipitated with aluminum hydroxide gel and the antibody response was observed. Both reaginic and γ1 antibodies were detected in the serum 10 days after the immunization and the antibody formation persisted for more than 1 month. The animals
Okudaira, H, Ishizaka, K
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Acta Endocrinologica, 1972
ABSTRACT The investigation shows that in a group of fifty-one patients with diabetes mellitus treated with pure porcine insulin preparation, administered as crystal suspension of protamin-insulin, 76 per cent formed antibodies reacting with insulin. None of the patients in the observation period developed insulin resistance.
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ABSTRACT The investigation shows that in a group of fifty-one patients with diabetes mellitus treated with pure porcine insulin preparation, administered as crystal suspension of protamin-insulin, 76 per cent formed antibodies reacting with insulin. None of the patients in the observation period developed insulin resistance.
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