Results 91 to 100 of about 447,696 (288)

Omalizumab: clinical use for the management of asthma [PDF]

, 2012
Omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, is a treatment option for patients with moderate to severe allergic asthma whose asthma is poorly controlled with inhaled corticosteroids and inhaled long-acting ß2 agonist ...
Rekha Chaudhuri, Neil C. Thomson, Thomson, N.C., Chaudhuri, R.   +3 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The inhibitory activity of secretions in cattle against foot and mouth disease virus. [PDF]

Natural and induced factors inhibiting foot and mouth disease virus were investigated in bovine secretions, especially in those from the upper respiratory and oro pharyngeal areas.
Garland, A. J. M
core   +1 more source

Relationship of IgG Avidity Index and IgM Levels for the Differential Diagnosis of Primary from Recurrent Cytomegalovirus Infections

Iranian Journal of Allergy, Asthma and Immunology, 2007
Since the incidence of symptomatic congenital cytomegalovirus infection is low (~0.05%) and risk factors are not well defined, it is difficult to develop strategies for prevention.
Anita Chakravarti, Bineeta Kashyap, Anupriya Wadhwa   +2 more
doaj  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Early-life nutritional and environmental determinants of thymic size in infants born in rural Bangladesh [PDF]

, 2009
The aim was to assess the impact of nutritional status and environmental exposures on infant thymic development in the rural Matlab region of Bangladesh.
Collinson, A. C.,, Collinson, AC, Prentice, AM, Vahter, M.,, Raqib, R, Arifeen, SE, R Raqib, Prentice, A. M.,, SE Moore, Prentice, A M, SE Arifeen, Fulford, AJC, Moore, SE, Moore, Sophie E, AC Collinson, Arifeen, S E, Vahter, M, Y Wagatsuma, Raqib, R.,, Persson, L A, Arifeen, S. E.,, Wagatsuma, Y.,, AJC Fulford, Moore, Sophie E.,, Vahter, M,, Fulford, A J C, Persson, LA, AM Prentice, LÅ Persson, Moore, Sophie E; id_orcid, Fulford, A. J. C.,, Collinson, A C, Persson, Lars-Åke,, Wagatsuma, Y, M Vahter   +34 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Antibody-dependent enhancement of HIV-1 infection.

, 2007
Antibody-dependent enhancement (ADE) is the process by which virus-specific antibodies enhance entry or replication of a virus, leading to increased infection and the potential to exacerbate disease progression or severity. In terms of HIV infection, ADE
Willey, S., Willey, Suzanne
core  

Data_Sheet_1_Impact of Disease-Modifying Treatments on the Longitudinal Evolution of Anti-JCV Antibody Index in Multiple Sclerosis.PDF

, 2018
Background: Risk of natalizumab-related progressive multifocal leukoencephalopathy is associated with the presence of anti-JC-virus (JCV) antibodies.Objective: To investigate the impact of disease-modifying treatments (DMT) on the longitudinal evolution ...
Gabriel Bsteh (3155535), Franziska Di Pauli (365013), Florian Deisenhammer (89557), Michael Auer (3155532), Janette Walde (3847330), Harald Hegen (3155538), Sebastian Wurth (4282057), Thomas Berger (72614), Anne Zinganell (5893949)   +8 more
core   +1 more source