Results 101 to 110 of about 447,696 (288)

Evaluation of selection strategies in dual-purpose and specialized breeding of indigenous chicken

Poultry Science
: This study aimed to evaluate various selection strategies for adoption in dual-purpose (ICD), meat (ICM) and layer (ICL) breeding goals in indigenous chicken breeding programs.
Sophie Miyumo, Chrilukovian B. Wasike, Evans D. Ilatsia, Jörn Bennewitz, Mizeck G.G. Chagunda   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Structure-Activity Relationships of Antibody-Drug Conjugates: A Systematic Review of Chemistry on the Trastuzumab Scaffold

, 2022
Antibody-drug conjugates (ADCs) are a rapidly growing class of cancer therapeutics. The goal of ADCs is to overcome the low therapeutic index of conventional cytotoxic agents. However, realizing this goal has been a significant challenge.
Pradeep , Shrestha, Ryan, Mclaughlin, Carol , Lipshultz, Martin, Schnermann, Siddharth, Matikonda   +4 more
core   +1 more source

Comparison of three serological chemiluminescence immunoassays for SARS-CoV-2, and clinical significance of antibody index with disease severity. [PDF]

PLoS One, 2021
Lee N, Jeong S, Park MJ, Song W.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Novel Immune Microlens Imaging for Detection of Antigen and Antibody

Journal of Immunology Research, 2019
Detection and analysis of antigen-antibody reaction is one of the most critical detection techniques in the fields of medicine, biology, environmental science, and food safety.
Jiahui Liang, Xiaotian Ye, Jiang He, Jing Liu, Yaoxiong Huang, Feiyue Xing   +5 more
doaj   +1 more source

The dynamic change of antibody index against Covid-19 is a powerful diagnostic tool for the early phase of the infection and salvage PCR assay errors. [PDF]

J Microbiol Immunol Infect, 2021
Omata M, Hirotsu Y, Sugiura H, Maejima M, Nagakubo Y, Amemiya K, Hayakawa M, Tsutsui T, Kakizaki Y, Mochizuki H, Miyashita Y.   +10 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Neuroimmunological approach for evaluation of viral measles, mumps and rubella triple vaccine

Revista Cubana de Investigaciones Biomédicas, 2019
Introduction: During the neuroinflammatory processes there are a poly-specific and polyclonal activation in the cerebrospinal fluid. It means that there can be quantified antibodies against all the components of the vaccines may have received. Objective:
William Castillo González, Mileydis Cruz Quevedo, José Alejandro Rodríguez Pérez, Eneida Barrios Lamoth, Cristóbal González Losada, Alberto Juan Dorta Contreras   +5 more
doaj  

Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya.

PLoS ONE, 2012
BackgroundAlthough antibodies are critical for immunity to malaria, their functional attributes that determine protection remain unclear. We tested for associations between antibody avidities to Plasmodium falciparum (Pf) antigens and age, asymptomatic ...
Frances Ibison, Ally Olotu, Daniel M Muema, Jedida Mwacharo, Eric Ohuma, Domtila Kimani, Kevin Marsh, Philip Bejon, Francis M Ndungu   +8 more
doaj   +1 more source