Results 111 to 120 of about 447,696 (288)
Journal of Visualized Experiments, 2019 Potentiation of hostile monoclonal antibodies (mAb) by chemotherapeutic agents constitutes a valuable strategy for designing effective and safer therapy against cancer. Here we provide a protocol to identify a rational combination at the preclinical step. First, we describe a cell-based assay to assess the synergism between anticancer mAb and cytotoxic
Bahri, Meriem +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Kampo Medicine, 2008 妊娠12週以内の初期流産を3回以上繰り返した，ANA，抗カルジオリピン抗体（ACA IgG, IgM）陽性習慣流産87例に柴苓湯療法を行い，抗体価（量）の推移を検討した。この結果，妊娠例（49例）の流産阻止率は63．3％，ANA陽性例（32例）の流産阻止率は65．6％，ACA IgG, IgM（fetal calf serum使用ELISA法）陽性（29例）は65．5％，両抗体陽性例（12例）は75．0％であった。ANAに対しては有意な低下作用は認められなかったが，ACA IgMに対しては有意な低下作用が認められた。文献的に柴苓湯の有効作用はTh1/Th2サイトカインバランス調整作用による液性免疫の抑制作用によると推察された。しかし，ACAが低下しなかった二生児獲得例が存在する事実から ...
KANO, Takashi +5 more
openaire +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018 We performed a cross-sectional study in 123 Chinese multiple sclerosis patients residing in Hong Kong to evaluate their anti-John Cunningham virus status using STRATIFY JCV DxSelect assays.
Alexander Lau +10 more
doaj +1 more source
Damage index in lupus: the role of antiphospholipid antibodies [PDF]
Lupus, 2019 M -C Amigo, P Alba
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
ANTISPERM ANTIBODY AND MALE INFERTILITY [PDF]
, 2019 Introduction: Antisperm antibody (ASA) in men cause autoimmune disease, respectively, immune infertility. DNA fragmentation is the separation or breaking of DNA strands in pieces.
Afrim Zeqiraj, Zehra Hajrulai-Musliu, Sadi Bexheti, Nexhbedin Beadini, Hesat Aliu, Zafer Gashi, Shkelzen Elezaj, Sheqibe Beadini, Agim Shabani*
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source