Results 61 to 70 of about 6,557,782 (278)
Clinical Cancer Research, 2019 Since the first approval of gemtuzumab ozogamicin (Mylotarg; Pfizer; CD33 targeted), two additional antibody–drug conjugates (ADC), brentuximab vedotin (Adcetris; Seattle Genetics, Inc.; CD30 targeted) and inotuzumab ozogamicin (Besponsa; Pfizer; CD22 ...
S. Coats +7 more
semanticscholar +1 more source
A comprehensive review of key factors affecting the efficacy of antibody drug conjugate.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 Antibody Drug Conjugate (ADC) is an emerging technology to overcome the limitations of chemotherapy by selectively targeting the cancer cells. ADC binds with an antigen, specifically over expressed on the surface of cancer cells, results decrease in ...
A. Samantasinghar +9 more
semanticscholar +1 more source
Antibody Reengineering Improves Therapeutic Index in Preclinical Models [PDF]
Cancer Discovery, 2013 Abstract An EGFR Probody exhibits antitumor efficacy similar to cetuximab, with decreased skin toxicity.
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Association between Body Mass Index and Hepatitis B antibody seropositivity in children [PDF]
Korean Journal of Pediatrics, 2019 Background The seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy.
Yoowon Kwon, Su Jin Jeong
doaj +1 more source
Case Reports in Neurology, 2013 Background: Myelitis is one of the rarest neurological complications of the varicella zoster virus (VZV) infection. Focal muscle weakness with or without sensory disturbance occurs in approximately 5% of the cases after acute VZV infection, with complete
Teruyuki Takahashi +9 more
semanticscholar +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Revista Cubana de Investigaciones Biomédicas, 2019 Introduction: The presence of IgG anti-Toxoplasma gondii has been used as an indicator to measure the naturally-acquired immune intrathecal response due to the polyclonal and polyspecific intrathecal response developed in neuroinflammation processes. The
Mileydis Cruz Quevedo +2 more
doaj
PLoS ONE, 2012 Background B cells and humoral immune responses play an important role in the pathogenesis and diagnosis of multiple sclerosis (MS). A characteristic finding in patients with MS is a polyspecific intrathecal B cell response against neurotropic viruses ...
B. Rosche +5 more
semanticscholar +1 more source
Therapeutic Index (TI) of Antibody-drug conjugates
, 2023 Therapeutic Index (TI) of Antibody-drug conjugates.
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