Results 51 to 60 of about 670,787 (298)

Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis. [PDF]

, 2017
Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress.
Angel Pujana, Miguel, Brunet, Joan, Chaldekas, Krysta, Chedin, Frederic, Chiang, Huai-Chin, Curiel, Tyler J, Elledge, Richard, Hu, Yanfen, Isaacs, Claudine, Jatoi, Ismail, Jin, Victor X, Lautner, Meeghan, Li, Rong, Mateo, Francesca, Michalek, Joel, Nair, Sreejith J, Ochoa, Oscar, Oliver, Boyce, Peshkin, Beth N, Petit, Anna, Poggi, Elizabeth, Smith, Sabrina, Soler, Teresa, Sun, Lu-Zhe, Theoharis, Constantine, Wang, Howard, Wang, Yao, Zhang, Chi, Zhang, Xiaowen, Zhao, Xiayan   +29 more
core   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Antibody Reengineering Improves Therapeutic Index in Preclinical Models [PDF]

Cancer Discovery, 2013
Abstract An EGFR Probody exhibits antitumor efficacy similar to cetuximab, with decreased skin toxicity.
openaire   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

The role of age in ocular toxoplasmosis: clinical signs of immunosenescence and inflammaging

Frontiers in Medicine
PurposeThis study aimed to investigate the association between age, immune response, and clinical presentation of ocular toxoplasmosis (OT).DesignThis was a monocentric, retrospective, observational cohort study.MethodsA review of the medical records of ...
Armin Taghavi Eraghi, Justus G. Garweg, Justus G. Garweg, Justus G. Garweg, Uwe Pleyer, Uwe Pleyer   +5 more
doaj   +1 more source

Concomitant Anti-hepatitis C positivity among family members of thalassemic patients

مجلة كلية الطب, 2010
Background: This study was carried out from first of June 2008 till first of June 2009 at thallassemia center Diyala governorate on families who have more than one affected member with thalassemia and other member who also gives positive results for ...
Dawood S. Hameed, Tareef F. Raham, Salwa Sh. Abdul wahid   +2 more
doaj   +1 more source

Protein Antigens Increase the Protective Efficacy of a Capsule-Based Vaccine against Staphylococcus aureus in a Rat Model of Osteomyelitis [PDF]

, 2014
Staphylococcus aureus is an invasive bacterial pathogen, and antibiotic resistance has impeded adequate control of infections caused by this microbe. Moreover, efforts to prevent human infections with single-component S. aureus vaccines have failed.
Buzzola, Fernanda Roxana, Denoël, Philippe, Germain, Sophie, Lattar, Santiago Martín, Lee, Jean C., Noto Llana, Mariangeles, Sordelli, Daniel Oscar   +6 more
core   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Assessment of Antibody-Titer Changes after Second and Third Severe Acute Respiratory Syndrome Coronavirus 2 mRNA Vaccination in Japanese Post-Kidney-Transplant Patients

Vaccines, 2023
Post-renal-transplant patients have a relatively low antibody-acquisition rate following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination.
Kumiko Fujieda, Akihito Tanaka, Ryosuke Kikuchi, Nami Takai, Shoji Saito, Yoshinari Yasuda, Takashi Fujita, Masashi Kato, Kazuhiro Furuhashi, Shoichi Maruyama   +9 more
doaj   +1 more source

Decrease in health-related quality of life associated with awareness of hepatitis C virus infection among people who inject drugs in Scotland [PDF]

, 2013
Chronic hepatitis C virus (HCV) infection can significantly reduce health-related quality of life (QoL), but it is not clear if reduction is associated with the infection or with being aware of one's infection status.
Allen, Elizabeth, Cameron, Sheila O., David J., Goldberg, Hutchinson, Sharon, McDonald, Scott, Palmateer, Norah Elizabeth, Taylor, Avril   +6 more
core   +1 more source