Results 51 to 60 of about 6,557,782 (278)
Conversion and reversion of anti‐John Cunningham virus antibody serostatus: A prospective study
Brain and Behavior, 2019 Introduction Determination of antibodies against the John Cunningham virus (JCV) is an important tool for risk stratification in Natalizumab‐treated multiple sclerosis (MS) patients.
Michael Auer +7 more
doaj +1 more source
Synovial antibody index as a marker of synovitis in knee osteoarthritis
Journal of Medicine and Palliative Care, 2022 As this is an editorial letter, no abstract avialable.
openaire +2 more sources
Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index [PDF]
Molecular Cancer Therapeutics, 2008 Abstract An anti-CD70 antibody conjugated to monomethylauristatin F (MMAF) via a valine-citrulline dipeptide containing linker has been shown previously to have potent antitumor activity in renal cell cancer xenograft studies. Here, we generated a panel of humanized anti-CD70 antibody IgG variants and conjugated them to MMAF to study ...
Charlotte F, McDonagh +13 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Cerebrospinal Fluid Research, 2005 Background An intrathecal polyspecific antibody response is a well known finding in multiple sclerosis. However, little is known about the evolution of intrathecal antibodies over time and their impact on the disease progress.
Reske Dirk, Petereit Hela-Felicitas
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Vaccines, 2023 Post-renal-transplant patients have a relatively low antibody-acquisition rate following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination.
Kumiko Fujieda +9 more
doaj +1 more source
Unlocking the potential of antibody–drug conjugates for cancer therapy
Nature Reviews Clinical Oncology, 2021 Nine different antibody–drug conjugates (ADCs) are currently approved as cancer treatments, with dozens more in preclinical and clinical development. The primary goal of ADCs is to improve the therapeutic index of antineoplastic agents by restricting ...
J. Drago, S. Modi, S. Chandarlapaty
semanticscholar +1 more source
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions
Clinics, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies' ability to neutralize the virus and confer long-term immunity.
Tatiana Carvalho de Souza Bonetti +9 more
openaire +5 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source