Results 91 to 100 of about 2,253,953 (246)

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Acute antibody-mediated rejection after pancreas transplantation [PDF]

Einstein (São Paulo), 2008
Objective: Acute antibody-mediated rejection requires specific treatment and has a negative impact on graft survival. The objectives were to report the incidence of antibody-mediated rejection after pancreas transplantation, the demographic data, the ...
Érika Bevilaqua Rangel, Denise Maria Avancini Costa Malheiros, Irina Antunes, Margareth Torres, Maria Cristina Ribeiro Castro, Fábio Crescentini, Tércio Genzini, Marcelo Perosa de Miranda   +7 more
doaj  

Dimensions of Antibody‐Mediated Rejection [PDF]

American Journal of Transplantation, 2010
In this issue, de Kort and colleagues report a thorough analysis of acute antibody-mediated rejection (acute AMR) in pancreas allografts. The study is an important practical reference for those working in the field of pancreas transplantation, and adds considerably to the number of published cases. The first message is that all grafts lost to rejection
openaire   +1 more source

Acute antibody-mediated rejection after ABO-incompatible kidney transplantation treated successfully with antigen-specific immunoadsorption

, 2010
ABO-incompatible kidney transplantation is possible after pre-treatment with rituximab, intravenous immunoglobulin and basiliximab combined with tacrolimus, mycophenolate mofetil and prednisolone. We report on the first patient treated with this protocol
Sprogøe, Ulrik, Koefoed-Nielsen, Pernille, Just, Søren Andreas; id_orcid, Bistrup, Claus; id_orcid, Marcussen, Niels; id_orcid   +4 more
core   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

T-cell-mediated Rejection of Vascularized Xenografts in the Absence of Induced Anti-donor Antibody Response: T cell mediated rejection

, 2002
International audienceT cells are considered to play a major indirect role in the pathogenesis of xenograft vascular rejection, by promoting the induction of anti-donor antibodies that trigger complement- and antibody-dependent cell cytotoxicity. However,
Guillet, Marina, Sébille, Fabien, Brouard, Sophie, Blancho, Gilles, Vanhove, Bernard, Gagne, Katia, Petzold, Thomas, Soulillou, Jean-Paul   +7 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Antibody-Mediated Rejection in Kidney Transplantation: A Review

, 2012
Antibody mediated rejection (AMR) poses a significant and continued challenge for long term graft survival in kidney transplantation. However, in the recent years, there has emerged an increased understanding of the varied manifestations of the antibody ...
Henkie P. Tan, Ron Shapiro, Chethan Puttarajappa   +2 more
core   +1 more source

Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies

Transplant International
Recently, interest in transcriptomic assessment of kidney biopsies has been growing. This study investigates the use of NGS to identify gene expression changes and analyse the pathways involved in rejection.
Esteban Cortes Garcia, Alessia Giarraputo, Maud Racapé, Valentin Goutaudier, Cindy Ursule-Dufait, Pierre de la Grange, Lucie Adoux, Marc Raynaud, Clément Couderau, Fariza Mezine, Jessie Dagobert, Oriol Bestard, Francesc Moreso, Jean Villard, Fabian Halleck, Magali Giral, Sophie Brouard, Richard Danger, Pierre-Antoine Gourraud, Marion Rabant, Lionel Couzi, Moglie Le Quintrec, Nassim Kamar, Emmanuel Morelon, François Vrtovsnik, Jean-Luc Taupin, Renaud Snanoudj, Christophe Legendre, Christophe Legendre, Dany Anglicheau, Dany Anglicheau, Klemens Budde, Carmen Lefaucheur, Carmen Lefaucheur, Alexandre Loupy, Alexandre Loupy, Olivier Aubert, Olivier Aubert   +37 more
doaj   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source