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Inheritance of Antibody Response [PDF]
The heritability of antibody response to sheep red cells (S.R.C.) was found to be 0 2836 0 1475 at 3 days and 0 1097 0 1165 at 6 days. These estimates are subject to environmental variation of measurement which was found subsequently but could not be corrected for.
WR Sobey, KM Adams
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ANTIBODY RESPONSES IN INFECTIOUS MONONUCLEOSIS [PDF]
Alan Bernstein
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Epigenetics of the antibody and autoantibody response [PDF]
B cell differentiation driven by microbial antigens leads to production of anti-microbial antibodies, such as those neutralizing viruses, bacteria or bacterial toxin, that are class-switched (IgG and IgA) and somatically hypermutated (maturation of the antibody response) as well as secreted in large volume by plasma cells. Similar features characterize
Justin B Moroney+4 more
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Epigenetics of the antibody response [PDF]
Epigenetic marks, such as DNA methylation, histone post-translational modifications and miRNAs, are induced in B cells by the same stimuli that drive the antibody response. They play major roles in regulating somatic hypermutation (SHM), class switch DNA recombination (CSR), and differentiation to plasma cells or long-lived memory B cells.
Hong Zan+3 more
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Potent and Persistent Antibody Response in COVID-19 Recovered Patients
SARS-CoV-2 has caused a global pandemic with millions infected and numerous fatalities. Virus-specific antibodies can be detected in infected patients approximately two weeks after symptom onset.
Xiaodong Tian+12 more
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Evaluation of the short-term and long-term immunological responses in a preclinical model that simulates the targeted age population with a relevant vaccination schedule is essential for human vaccine development.
Céline Vaure+5 more
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Crosstalk between T and B cells is crucial for generating high-affinity, class-switched antibody responses. The roles of CD4+ T cells in this process have been well-characterised.
Timona S. Tyllis+9 more
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A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity [PDF]
Malaria is a global health concern and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum ...
Bosch, A.+15 more
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The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults [PDF]
This study determined whether stressful life events and social support were related to antibody status following both thymus-dependent and thymus-independent vaccinations. Life events in the previous year and customary social support were measured in 57
Burns, Victoria E.+4 more
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ZBTB38 is dispensable for antibody responses
Members of the broad complex, tram track, bric-a-brac and zinc finger (BTB-ZF) family of transcription factors, such as BCL-6, ZBTB20, and ZBTB32, regulate antigen-specific B cell differentiation, plasma cell longevity, and the duration of antibody production.
Deepta Bhattacharya+2 more
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