Results 201 to 210 of about 1,478,450 (299)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Prevalence of antigliadin IgA antibodies in psoriasis vulgaris and response of seropositive patients to a gluten-free diet

, 2017
Nikolai A Kolchak, Maria K Tetarnikova, Maria S Theodoropoulou, Alexandra P Michalopoulou, Demetrios S. Theodoropoulos   +4 more
openalex   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

The association between depressive symptoms and antibody response following SARS-CoV-2 vaccination among central North Carolina residents. [PDF]

PLOS Ment Health
Cassidy CA, Edwards JK, Gunderson AK, Abernathy H, Garrett HE, King E, Parker CNB, Starling AP, Ciccone EJ, Boyce RM, Shook-Sa BE, Aiello AE.   +11 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas. [PDF]

Blood Adv
Sarathkumara YD, Van Bibber NW, Liu Z, Heslop HE, Rouce RH, Coghill AE, Rooney CM, Proietti C, Doolan DL.   +8 more
europepmc   +1 more source

Interleukin 8 as a Causal Link Between Aging and Impaired Influenza Antibody Responses in Older Adults

Huy Quang Quach, Krista M. Goergen, Diane E. Grill, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy   +5 more
openalex   +2 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Image 1_Circulating SARS-CoV-2 spike IgG antibody responses in cancer patients following multiple COVID-19 vaccination boosters.tif

Huijing Xue (22037999), Troy J. Kemp (14967472), Hayley North (22038002), Nancy V. Roche (15290081), Thomas E. Hickey (2466436), Ligia A. Pinto (14967487)   +5 more
openalex   +1 more source

Induction of neutralizing antibody responses by AAV5-based vaccine for respiratory syncytial virus in mice [PDF]

Guangxu Ma, Zeping Xu, Chinyu Li, Feng Zhou, Branda Hu, Junwei Guo, Changwen Ke, Liqing Chen, Guilin Zhang, Hungyan Lau, Hudan Pan, Xixin Chen, Runze Li, Liang Liu   +13 more
openalex   +1 more source