Results 121 to 130 of about 1,873,489 (255)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Specificity Controls for Immunocytochemical Methods

, 2000
Immunocytochemistry is used for antibody localization of proteins in cells and tissues. The specificity of the results depends on two independent criteria: the specificity of the antibody and of the method used.
Richard W. Burry
core   +1 more source

From antibody specificity to T cell recognition. [PDF]

J Exp Med, 2021
Kim HJ, Cantor H.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Immunochemical studies on barley seed storage proteins. The specificity of an antibody to 'C' hordein and its reaction with prolamins from other cereals

, 1984
The antigenic relationships between the prolamins of barley, rye and wheat have been studied by examining the specificity of an antibody to ‘C’ hordein in a quantitative study using a laser nephelometer.
Miflin, B. J., Shewry, P. R., Festenstein, G. N., Hay, F. C., Miflin, Benjamin J., Shewry, Peter   +5 more
core   +1 more source

Importance of establishing antibody specificity in multisystem inflammatory syndrome in newborn during the COVID-19 pandemic. [PDF]

Acta Paediatr, 2023
Leslie AT, Saleh M, Soni N, Tang P, Kallem V, Tscherning C, More K.   +6 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point. [PDF]

iScience, 2022
Screnci B, Stafford LJ, Barnes T, Shema K, Gilman S, Wright R, Al Absi S, Phillips T, Azuelos C, Slovik K, Murphy P, Harmon DB, Charpentier T, Doranz BJ, Rucker JB, Chambers R.   +15 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Diagnostic specificity of the Enferplex Bovine TB antibody test using individual milk samples from UK cattle.

Diagnostic specificity of the Enferplex Bovine TB antibody test using individual milk samples from UK cattle.
Alastair Hayton (18468915), Keith Cutler (18468918), Andy Adler (613118), Darren J. Shaw (12906848), Gordon D. Harkiss (18468924), Amanda O’Brien (18468912), Neil Watt (18468921), John Clarke (7869)   +7 more
core   +1 more source