Results 111 to 120 of about 678,918 (305)

Antibodies specific to a deoxyribodinucleotide sequence

Nucleic Acids Research, 1977
Antibodies were raised in rabbits against the bovine serum albumin conjugate of dpApT. Analysis by double diffusion in agar gel and quantitative precipitation test showed the presence of antibodies specific to the hapten in the antisera. Quantitative data on the specificity of the antibodies were obtained by studying the inhibition of the binding of 3H-
S A, Khan, M Z, Humayun, T M, Jacob
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Antibody targeted nanoparticles for imaging and therapy of cancer [PDF]

, 2010
The central hypothesis for this thesis is that antibody-targeted superparamagnetic iron oxide nanoparticles (SPIONs) can be used for diagnosis and therapy of cancer.
Vigor, K.L.
core  

nicwulab/HA_Abs: mBLM for antibody specificity prediction [PDF]

<p>About The repository includes all custom scripts and deep learning model code associated with the paper titled "An Explainable Language Model for Antibody Specificity Prediction Using Curated Influenza Hemagglutinin Antibodies.</p ...
Nicholas Wu, Yiquan Wang
core   +3 more sources

A Western Blot and Immunoprecipitation Assay to Verify Antibody Specificity

BioTechniques, 2015
Life scientists are raising awareness of the problem of irreproducible data in basic research (1) (2). Part of the crisis of irreproducibility has been blamed on antibodies (3), and from this standpoint, an equal push to bring awareness to antibody ...
Sharon Bonnette
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. [PDF]

, 2011
BACKGROUND: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.
Vidyagouri Shinde, Lavanya Suneetha, Karuna Devi, Wim H. van Brakel, Shinde, V., Suneetha Lavanya, Diana N J Lockwood, Jadhav, Rupendra, Nicholls Peter G., Peter G Nicholls, Chaduvula Meher Vani, Suneetha, L., Kamble Ravindra, Devi, K., Raju, Renuka, Jadhav Rupendra, Devi Karuna, Peter G. Nicholls, Diana N. J. Lockwood, Kamble, Ravindra, Lockwood, Diana NJ, Jadhav, R., Chaduvula, M.V., Suneetha, Sujai, Lockwood, D.N.J., Suneetha Sujai, Suneetha, Lavanya, van Brakel, Wim H, van Brakel Wim H., Wim H van Brakel, Raju, R., Suneetha, S., Devi, Karuna, Sujai Suneetha, Nicholls, Peter G, Kamble, R., Lockwood Diana N. J., Rupendra Jadhav, Nicholls, P.G., Shinde, Vidyagouri, Chaduvula, Meher Vani, Shinde Vidyagouri, van Brakel, W.H., Raju Renuka, Renuka Raju, Ravindra Kamble, Meher Vani Chaduvula   +46 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Limited antigenic diversity of Plasmodium falciparumapical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
Background: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism.
Drew, Damien R., Anders, Robin, Sheetij Dutta, Cross, Nadia, Senn, Nicolas, Hodder, AN, Dutta, Sheetij, Nicolas Senn, Osier, Faith H. A., Terheggen, Ulrich, Hodder, Anthony, Damien R Drew, Beeson, JG, Nadia J Cross, James G Beeson, Mugyenyi, Cleopatra, Osier, FHA, Alyssa E Barry, Ulrich Terheggen, Hodder, Anthony N., Barry, Alyssa, Siba, Peter, Mueller, I, Siba, PM, Beeson, James, Drew, DR, Stanisic, Danielle I., Terheggen, U, Anders, RF, Beeson, James G., Peter M Siba, Dutta, S, Cross, Nadia J., Stanisic, Danielle, Kevin Marsh, Faith HA Osier, Elliott, Salenna, Barry, AE, Jack S Richards, Anders, Robin F., Barry, Alyssa E., Elliott, Salenna R., Senn, N, Danielle I Stanisic, Stanisic, DI, Mueller, Ivo, Richards, Jack, Ivo Mueller, Marsh, K, Elliott, SR, Richards, Jack S., Drew, Damien, Anthony N Hodder, Mugyenyi, Cleopatra K., Cleopatra K Mugyenyi, Osier, Faith, Richards, JS, Robin F Anders, Cross, NJ, Salenna R Elliott, Marsh, Kevin, Mugyenyi, CK, Siba, Peter M.   +62 more
core   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source