Results 91 to 100 of about 969,569 (304)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

HIV Specific Humoral Immune Response in Rio de Janeiro, Brazil

Memorias do Instituto Oswaldo Cruz, 1998
Efforts to characterize HIV-1 polymorphism and anti-HIV immune response are being made in areas where anti-HIV/AIDS vaccines are to be employed. Anti-HIV-1 humoral immune response is being studied in infected individuals resident in Rio de Janeiro, in ...
Bongertz V, Costa CI, Guimarães ML, Soares-da-Costa MFG, Grinsztejn B, Bastos FI, Pilotto JH, João Filho EC, Loureiro R, Chequer P, Telles PR, Galvão-Castro B, Morgado MG   +12 more
doaj  

Preparation and Characterization of Monoclonal Antibodies Against the Porcine Rotavirus VP6 Protein

Veterinary Sciences
Porcine Rotavirus (PoRV), a predominant causative agent of neonatal diarrhea in piglets, shares substantial genetic homology with human rotavirus and represents a considerable threat to both public health and the global swine industry in the absence of ...
Botao Sun, Dingyi Mao, Jing Chen, Xiaoqing Bi, Linke Zou, Jishan Bai, Rongchao Liu, Ping Hao, Qi Wang, Linhan Zhong, Panchi Zhang, Bin Zhou   +11 more
doaj   +1 more source

Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires

, 2017
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in ...
Afzal, Ahmed, Albert, Amanna, Andrews, Angermueller, Apeltsin, Arden, Atchley, Avnir, Barabási, Barak, Bashford-Rogers, Bastian, Baum, Becattini, Ben-Hamo, Berger, Betz, Boc, Bolen, Bolkhovskaya, Bolotin, Bouckaert, Boyd, Boyd, Breden, Brown, Burnet, Bürckert, Calis, Castro, Chang, Chao, Chen, Ching, Cobey, Collins, Corcoran, Covacu, Csardi, Cui, Dash, de Bourcy, DeKosky, DeKosky, DeWitt, Dziubianau, Elhanati, Elhanati, Elhanati, Ellebedy, Emerson, Felsenstein, Friedensohn, Gadala-Maria, Galson, Galson, Geering, Georgiou, Ghraichy, Giribet, Giudicelli, Glanville, Glanville, Glanville, Good, Granato, Greiff, Greiff, Greiff, Greiff, Greiff, Grigaityte, Guindon, Gupta, Gupta, Hagberg, Halliley, Hammarlund, Heather, Hershberg, Hochreiter, Hoehn, Hoehn, Hoehn, Horns, Howie, Iversen, Jackson, Janeway, Jiang, Johnston, Jost, Jurtz, Kaplinsky, Kaplinsky, Kendall, Khavrutskii, Kidd, Kidd, Kidera, Kirik, Konishi, Kumar, Landsverk, Larkin, Lavinder, Laydon, Laydon, Lee, Lee, Lewitus, Li, Lindeman, Lindner, Liu, Love, Lozupone, Madi, Madi, Malissen, Mamoshina, Mangul, Manz, Martin, Meng, Miho, Mora, Morisita, Murugan, Nazarov, Nouri, Oakes, Ostmeyer, Paradis, Parameswaran, Parola, Pinheiro, Pollok, Ralph, Ravn, Reddy, Rempala, Rempala, Revell, Rizzetto, Robinson, Ronquist, Roybal, Rubelt, Rubelt, Safonova, Schliep, Schramm, Schwab, Shannon, Sheng, Sheng, Shlemov, Shugay, Shugay, Shugay, Snir, Snir, Stamatakis, Stern, Strauli, Stubbington, Stubbington, Sun, Sun Cinelli, Swofford, Thomas, Tickotsky, Tonegawa, Torkamani, Trepel, VanDuijn, Venturi, Venturi, Vieira, Vita, Wang, Wardemann, Warren, Watson, Watson, Watson, Weinstein, Wine, Wine, Wu, Yaari, Yaari, Yang, Yeap, Yermanos, Yokota, Yu, Zhu   +200 more
core   +1 more source

Comparison of bulk milk antibody and youngstock serology screens for determining herd status for Bovine Viral Diarrhoea Virus [PDF]

, 2016
BACKGROUND: This paper examines the use of Bulk Milk antibody (BM Ab), Youngstock (YS) serology (Check Tests) and Bulk Milk PCR (BM PCR) for determining the presence or absence of animals persistently infected (PI) with Bovine Viral Diarrhoea Virus (BVDV)
A Lindberg, A Moerman, A Uttenthal, AL Lindberg, AW Stott, B Fredriksen, C Wray, E Peterhans, G Pritchard, GJ Gunn, H Houe, H Houe, H Houe, H Houe, H Houe, J Brownlie, JA Ellis, Joe Brownlie, LN Potgieter, MF Chamorro, MH Mars, MR McGowan, P Presi, P Virakul, PS Valle, R Bennett, R Niskanen, R Niskanen, RE Booth, RE Booth, Richard E. Booth, RM Barlow, S Edwards, S Sarrazin, TW Drew, V Moennig   +35 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monoclonal IgM antibodies mediate potent complement neutralization by targeting cell-derived epitopes on enveloped viruses

mBio
When studying virus neutralization by specific antibodies of the adaptive immune response, serum heat treatment is a standard procedure done to eliminate any non-specific effects by the complement system.
Markus H. Kainulainen, Jessica R. Harmon, Éric Bergeron, Katherine A. Davies, Morgan L. LeBlanc, Cristina Clines, Meghan L. Bentz, Joel M. Montgomery, Christina F. Spiropoulou   +8 more
doaj   +1 more source

Characterization of a monoclonal antibody with specificity for holo-transcobalamin

Nutrition & Metabolism, 2006
Background Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant.
Fedosov Sergey N, Brady Jeff, Campbell Andrew, Rian Anne, Orning Lars, Bramlage Birgit, Thompson Keith, Quadros Edward V   +7 more
doaj   +1 more source

Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays. [PDF]

, 2019
The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas ...
Arranz-Solís, David, Commodaro, Alessandra G, Cordeiro, Cynthia, Dardé, Marie Laure, Grigg, Michael E, Saeij, Jeroen PJ, Young, Lucy H   +6 more
core   +1 more source

Neurocysticercosis without Detectable Specific Antibody.

Internal Medicine, 1999
A 19-year-old girl who had lived in India for five years until 1992 was admitted to Hokuto Hospital after general seizures which lasted for fifteen minutes. Cerebral magnetic resonance imaging (MRI) showed a ring-enhanced lesion of 6 mm in diameter in the right parietal lobe.
Y, Ohsaki, A, Matsumoto, K, Miyamoto, N, Kondoh, K, Araki, A, Ito, K, Kikuchi   +6 more
openaire   +3 more sources