Results 91 to 100 of about 1,781,035 (303)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability
Cell Reports, 2019 Summary: Monoclonal antibodies (mAbs) have recently emerged as one of the most promising classes of biotherapeutics. A potential advantage of B cell-derived mAbs as therapeutic agents is that they have been subjected to natural filtering mechanisms ...
Laila Shehata +11 more
doaj +1 more source
Panel demonstrating antibody specificity for SIRT1-7.
, 2015 For each sirtuin antibody a negative control (antibody diluent only) is illustrated, along with a tissue core stained with the antibody. Antibody specificity was validated via the use of blocking peptide to compete with tissue staining, or IHC on ...
Liane M. McGlynn (148841) +9 more
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
HIV Specific Humoral Immune Response in Rio de Janeiro, Brazil
Memorias do Instituto Oswaldo Cruz, 1998 Efforts to characterize HIV-1 polymorphism and anti-HIV immune response are being made in areas where anti-HIV/AIDS vaccines are to be employed. Anti-HIV-1 humoral immune response is being studied in infected individuals resident in Rio de Janeiro, in ...
Bongertz V +12 more
doaj
Preparation and Characterization of Monoclonal Antibodies Against the Porcine Rotavirus VP6 Protein
Veterinary SciencesPorcine Rotavirus (PoRV), a predominant causative agent of neonatal diarrhea in piglets, shares substantial genetic homology with human rotavirus and represents a considerable threat to both public health and the global swine industry in the absence of ...
Botao Sun +11 more
doaj +1 more source
The specificity of IGF signaling antibody arrays.
, 2013 The specificity of IGF signaling antibody arrays.
Ying-Qing Mao (303110) +9 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
mBioWhen studying virus neutralization by specific antibodies of the adaptive immune response, serum heat treatment is a standard procedure done to eliminate any non-specific effects by the complement system.
Markus H. Kainulainen +8 more
doaj +1 more source
Characterization of a monoclonal antibody with specificity for holo-transcobalamin
Nutrition & Metabolism, 2006 Background Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant.
Fedosov Sergey N +7 more
doaj +1 more source