Results 71 to 80 of about 678,918 (305)

Induction of viral and tumour specific CTL responses using antibody targeted HLA class I peptide complexes. [PDF]

, 2002
The production of cytotoxic T cells with specificity for cancer cells is a rapidly evolving branch of cancer therapeutics. A variety of approaches aim to amplify anti-tumour cytotoxic T cell responses using purified peptides, tumour cell lysates or ...
Savage, Philip, McMichael, Andrew, Savage, P, P Cowburn, Lemoine, Nick, Clayton, A, Man, S, A McMichael, Epenetos, Agamemnon, S Man, Ogg, G, G Ogg, Cowburn, Pam, Cowburn, P, A Clayton, P Savage, A Epenetos, Clayton, Aled, N Lemoine, McMichael, A, Epenetos, A, Man, Stephen Tzekwung, Ogg, Graham, Lemoine, N   +23 more
core   +1 more source

Limited Specificity of Serologic Tests for SARS-CoV-2 Antibody Detection, Benin

Emerging Infectious Diseases, 2021
We used commercially available ELISAs to test 68 samples from coronavirus disease cases and prepandemic controls from Benin. We noted
Anges Yadouleton, Anna-Lena Sander, Andres Moreira-Soto, Carine Tchibozo, Gildas Hounkanrin, Yvette Badou, Carlo Fischer, Nina Krause, Petas Akogbeto, Edmilson F. de Oliveira Filho, Anges Dossou, Sebastian Brünink, Melchior A. Joël Aïssi, Mamoudou Harouna Djingarey, Benjamin Hounkpatin, Michael Nagel, Jan Felix Drexler   +16 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The effect of daily co-trimoxazole prophylaxis on natural development of antibody-mediated immunity against P. falciparum malaria infection in HIV-exposed uninfected Malawian children. [PDF]

, 2015
BACKGROUND AND OBJECTIVES: Co-trimoxazole prophylaxis, currently recommended in HIV-exposed, uninfected (HEU) children as protection against opportunistic infections, also has some anti-malarial efficacy.
Tom Hall (712080), Kamija S Phiri, Gondwe, Thandile, Jambo, Kondwani C, Tetteh, Kevin KA, Longwe, Herbert, Chris Drakeley (79962), Wilson L. Mandala (360369), Drakeley, Chris, Kevin K A Tetteh, Phiri, Kamija S, Chris Drakeley, Nyanyiwe Mbeye, Mandala, Wilson L, Nyanyiwe Mbeye (712078), Tom Hall, Kondwani C. Jambo (159487), Kevin K. A. Tetteh (122339), Wilson L Mandala, Thandile Gondwe (712079), Herbert Longwe (712077), Herbert Longwe, Thandile Gondwe, Mbeye, Nyanyiwe, Kamija S. Phiri (52377), Hall, Tom, Kondwani C Jambo   +26 more
core   +1 more source

Understanding and Modulating Antibody Fine Specificity: Lessons from Combinatorial Biology

Antibodies, 2022
Combinatorial biology methods such as phage and yeast display, suitable for the generation and screening of huge numbers of protein fragments and mutated variants, have been useful when dissecting the molecular details of the interactions between ...
Gertrudis Rojas
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Specificity and overlap in gene segment-defined antibody repertoires

BMC Genomics, 2005
Background To date several studies have sought to catalog the full suite of antibodies that humans naturally produce against single antigens or other specificities (repertoire).
Arnaout Ramy A
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Selective measurement of anti-tTG antibodies in coeliac disease and IgA deficiency : an alternative pathway [PDF]

, 2013
Objective To determine the ability of selective antibody testing to screen for coeliac disease in the presence of IgA deficiency and to define the sensitivity of a pathway using this method (Figure1).
Arasaradnam, Ramesh P., Nwokolo, Chuka U., Harrison, Elizabeth, Loft, Duncan, Liu, Kuo-Kang, Petchey, Michael   +5 more
core   +1 more source