Results 71 to 80 of about 1,781,035 (303)

Induction of viral and tumour specific CTL responses using antibody targeted HLA class I peptide complexes. [PDF]

, 2002
The production of cytotoxic T cells with specificity for cancer cells is a rapidly evolving branch of cancer therapeutics. A variety of approaches aim to amplify anti-tumour cytotoxic T cell responses using purified peptides, tumour cell lysates or ...
Savage, Philip, McMichael, Andrew, Savage, P, P Cowburn, Lemoine, Nick, Clayton, A, Man, S, A McMichael, Epenetos, Agamemnon, S Man, Ogg, G, G Ogg, Cowburn, Pam, Cowburn, P, A Clayton, P Savage, A Epenetos, Clayton, Aled, N Lemoine, McMichael, A, Epenetos, A, Man, Stephen Tzekwung, Ogg, Graham, Lemoine, N   +23 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Specificity and overlap in gene segment-defined antibody repertoires

BMC Genomics, 2005
Background To date several studies have sought to catalog the full suite of antibodies that humans naturally produce against single antigens or other specificities (repertoire).
Arnaout Ramy A
doaj   +1 more source

Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity

, 2023
Antibody–drug conjugates (ADCs) constitute a rapidly expanding category of biopharmaceuticals that are reshaping the landscape of targeted chemotherapy.
Jezabel Garcia-Parra, Lewis Webb Francis, Robert Steven Conlan, Deyarina Gonzalez, Emenike Kenechi Onyido, John Sinfield, Zoe Coombes, Anna Moberg, Nicole Williams, David James, Jenny Worthington   +10 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]

, 2007
Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Yiannis Ioannou, Lambrianides, A., Anisur Rahman, Isenberg, D.A., Lesley Mason, Giles, I., Ioannou, Y., Latchman, D.S., Mason, L., Jessica J. Manson, Ian Giles, Manson, J.J., David A. Isenberg, David S. Latchman, Rahman, A., Anastasia Lambrianides   +15 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Antibodies to guanosine [PDF]

FEBS Letters, 1984
Bovine serum albumin conjugates of guanosine prepared by the periodate method was used as immunogen to elicit guanosine antibodies in rabbits. The specificities of the antibodies were studied by the inhibition of their binding to [3H]Gox‐red, [32P]DNA and [3H]RNA by related non‐radioactive compounds.
Iswari, S, Jacob, TM
openaire   +2 more sources

The effect of daily co-trimoxazole prophylaxis on natural development of antibody-mediated immunity against P. falciparum malaria infection in HIV-exposed uninfected Malawian children. [PDF]

, 2015
BACKGROUND AND OBJECTIVES: Co-trimoxazole prophylaxis, currently recommended in HIV-exposed, uninfected (HEU) children as protection against opportunistic infections, also has some anti-malarial efficacy.
Tom Hall (712080), Kamija S Phiri, Gondwe, Thandile, Jambo, Kondwani C, Tetteh, Kevin KA, Longwe, Herbert, Chris Drakeley (79962), Wilson L. Mandala (360369), Drakeley, Chris, Kevin K A Tetteh, Phiri, Kamija S, Chris Drakeley, Nyanyiwe Mbeye, Mandala, Wilson L, Nyanyiwe Mbeye (712078), Tom Hall, Kondwani C. Jambo (159487), Kevin K. A. Tetteh (122339), Wilson L Mandala, Thandile Gondwe (712079), Herbert Longwe (712077), Herbert Longwe, Thandile Gondwe, Mbeye, Nyanyiwe, Kamija S. Phiri (52377), Hall, Tom, Kondwani C Jambo   +26 more
core   +2 more sources