Results 61 to 70 of about 1,873,489 (255)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Antibody production in transgenic plants

, 2022
S.301-318Antibodies bind with great affinity and specificity to their target antigens, allowing them to be exploited in research, medicine, agriculture, and industry.
Christou, P., Twyman, R.M., Fischer, R., Stoger, E., Schillberg, S.   +4 more
core  

Relation-Aware Equivariant Graph Networks for Epitope-Unknown Antibody Design and Specificity Optimization [PDF]

Antibodies are Y-shaped proteins that protect the host by binding to specific antigens, and their binding is mainly determined by the Complementary Determining Regions (CDRs) in the antibody.
Wu, Lirong, Wu, Tailin, Tan, Cheng, Liu, Yunfan, Huang, Yufei, Li, Stan Z., Lin, Haitao, Gao, Zhangyang   +7 more
core   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Antibodies for immunolabeling by light and electron microscopy : not for the faint hearted [PDF]

, 2014
Reliable antibodies represent crucial tools in the arsenal of the cell biologist and using them to localize antigens for immunocytochemistry is one of their most important applications.
Lucocq, John Milton, Griffiths, Gareth, John Milton Lucocq, Gareth Griffiths   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains [PDF]

, 2014
Two long synthetic peptides representing the dimorphic and constant C-terminal domains of the two allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates.
Kajava, Andrey V., Diakité, Mahamadou, Felger, Ingrid, Servis, Catherine, Corradin, Giampietro, D’Alessandro, Alba, Moret, Remy, Balam, Saidou, Nebie, Issa, Kajava, Andrey V, Spertini, François, Olugbile, Sope, Smith, Thomas, D'Alessandro, Alba, Frank, Geraldine, Tanner, Marcel, D'Alessandro A, Tanner, M., Diakité M, Olugbile, S., Spertini F, Frank, G., Olugbile S, Balam S, Servis C, Moret R, Smith, T., Corradin G, Servis, C., Diakité, M., Spertini, F., Kajava AV, Frank G, Moret, R., Nebie, I., Nebie I, Felger, I., Corradin, G., Smith T, D'Alessandro, A., Kajava, A.V., Tanner M, Balam, S., Felger I   +43 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses. [PDF]

, 2016
Emerging data support a role for antibody Fc-mediated antiviral activity in vaccine efficacy and in the control of HIV-1 replication by broadly neutralizing antibodies.
Thaddeus C Gurley (3140499), Agnès-Laurence Chenine (377199), Hua-Xin Liao (161409), Michael D McRaven (3140487), Agnès-Laurence Chenine, Matthew Zirui Tay, Thomas J. Hope, Thomas J Hope, Barton F. Haynes, S Moses Dennison, Sheetal Sawant, Sheetal Sawant (3140496), S. Munir Alam, LaTonya D Williams, Thomas T. Xu, S. Moses Dennison (194568), Thaddeus C Gurley, Thomas J. Hope (108657), Barton F. Haynes (140266), Pinghuang Liu (779149), Georgia D. Tomaras, Georgia D Tomaras, Barton F Haynes, Hua-Xin Liao, Pinghuang Liu, S Munir Alam, LaTonya D. Williams (3140490), Thomas T Xu, Georgia D. Tomaras (164058), Matthew Zirui Tay (3140493), S. Moses Dennison, S. Munir Alam (164023), Michael D McRaven, M Anthony Moody, LaTonya D. Williams, M. Anthony Moody (164063), M. Anthony Moody, Thomas T. Xu (3140502)   +37 more
core   +1 more source

Characterization of Primate Antibody Responses to Administered Murine Monoclonal Immunoglobulin

The International Journal of Biological Markers, 1990
Murine monoclonal antibodies (MAb) are currently being assessed for their utility as tools in cancer management. Anti-murine immunoglobulin responses have been observed in many patients receiving monoclonal antibody treatment. In this study, we evaluated
D.E. Milenic, B. Detrick, J.C. Reynolds, D. Colcher   +3 more
doaj   +1 more source