Results 41 to 50 of about 678,918 (305)

Specific Suppression of the Antibody Response by Antibodies to Receptors [PDF]

Proceedings of the National Academy of Sciences, 1972
Balb/c myeloma proteins, TEPC 15 and MOPC 167, bind phosphorylcholine and precipitate with the C-polysaccharide moiety of pneumococci R36A. Anti-idiotypic antibodies to TEPC 15 myeloma raised in A/He mice prevent plaque formation by cells releasing antibody to phosphorylcholine and inhibit induction of the antibody response to ...
Cosenza, H, Kohler, H
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Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains [PDF]

, 2014
Two long synthetic peptides representing the dimorphic and constant C-terminal domains of the two allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates.
Kajava, Andrey V., Diakité, Mahamadou, Felger, Ingrid, Servis, Catherine, Corradin, Giampietro, D’Alessandro, Alba, Moret, Remy, Balam, Saidou, Nebie, Issa, Kajava, Andrey V, Spertini, François, Olugbile, Sope, Smith, Thomas, D'Alessandro, Alba, Frank, Geraldine, Tanner, Marcel   +15 more
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Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection [PDF]

, 2010
Rituximab, a monoclonal antibody which targets CD20 on B-cells, is now central to the treatment of a variety of malignant and autoimmune disorders. Despite this success a substantial proportion of B-cell lymphomas are unresponsive or develop resistance ...
French, R.R., Johnson, P.W.M., Cox, Kerry L., Chan, Claude H.T., Johnston, David A., Glennie, Martin J., Jarrett, T.C., Glennie, M.J., Verbeek, Sjef, Chan, H.T.C., Dixon, S.V., Mora Vidal, Regina, Wijayaweera, Sahan S., Cragg, Mark S., Lim, Sean H., Dixon, Sandra V., Verbeek, J.S., French, Ruth R., Wijayaweera, S.S., Jarrett, Timothy C., Cragg, M.S., Kim, Hyung J., Kerr, Jonathan P., Vidal, R.M., Johnston, D.A., Lim, S.H., Cox, K.L., Kerr, J.P., Johnson, Peter W.M., Beers, Stephen A., Kim, H., Beers, S.A.   +31 more
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Strategies for immunohistochemical protein localization using antibodies: What did we learn from neurotransmitter transporters in glial cells and neurons [PDF]

, 2016
Immunocytochemistry and Western blotting are still major methods for protein localization, but they rely on the specificity of the antibodies. Validation of antibody specificity remains challenging mostly because ideal negative controls are often ...

core   +1 more source

Unconstrained generation of synthetic antibody–antigen structures to guide machine learning methodology for antibody specificity prediction [PDF]

, 2022
Machine learning (ML) is a key technology for accurate prediction of antibody–antigen binding. Two orthogonal problems hinder the application of ML to antibody-specificity prediction and the benchmarking thereof: the lack of a unified ML formalization of
Hochreiter, Sepp, Prósz, Aurél, Abram, Krzysztof, Snapkov, Igor, Scheffer, Lonneke, Mehta, Brij Bhushan, Lund-Johansen, Fridtjof, Sandve, Geir Kjetil, Mathisen, Ingvild Frøberg, Slabodkin, Andrei, Miho, Enkelejda, Rawat, Puneet, Haff, Ingrid Hobæk, Chernigovskaya, Maria, Widrich, Michael, Vu, Mai Ha, Greiff, Victor, Hobæk Haff, Ingrid, Klambauer, Günter, Olar, Axel, Olar, Alex, Robert, Philippe A., Akbar, Rahmad, Frank, Robert, Pavlović, Milena, Smorodina, Eva, Haug, Dag Trygve Tryslew   +26 more
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The Complexity of Antibody Responses Elicited against the Respiratory Syncytial Virus Glycoproteins in Hospitalized Children Younger than 2 Years

Frontiers in Microbiology, 2017
The influence of age and maternal antibodies on the antibody responses to human respiratory syncytial virus (hRSV) glycoproteins in very young children has been a matter of controversy.
Alfonsina Trento, Alfonsina Trento, Rosa Rodríguez-Fernández, María I. González-Sánchez, Felipe González-Martínez, Vicente Mas, Vicente Mas, Mónica Vázquez, Mónica Vázquez, Concepción Palomo, Concepción Palomo, José A. Melero, José A. Melero   +12 more
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Antibody variable region engineering for improving cancer immunotherapy

Cancer Communications, 2022
The efficacy and specificity of conventional monoclonal antibody (mAb) drugs in the clinic require further improvement. Currently, the development and application of novel antibody formats for improving cancer immunotherapy have attracted much attention.
Hantao Lou, Xuetao Cao
doaj   +1 more source

Antibody-drug conjugates for cancer therapy [PDF]

, 2020
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent ...
Sagun Parakh (9493061), Umbreen Hafeez (9474611), Andrew Scott (9483443), Hui Gan (9477872)   +3 more
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Molecular chaperone effects on recombinant yield and binding characteristics of an ABA-specific scFv in Escherichia coli

Frontiers in Bioengineering and Biotechnology
IntroductionRecombinant single‐chain variable fragments (scFvs) are promising antibody formats for cost‐effective and scalable production. However, their soluble expression in Escherichia coli is often limited by misfolding and aggregation, particularly ...
Shimiao Chen, Shimiao Chen, Shimiao Chen, Bin Shan, Bin Shan, Yican Luo, Ganhui Mo, Ganhui Mo, Ganhui Mo, Usman Rasheed, Usman Rasheed, Usman Rasheed, Lilan Lv, Lilan Lv, Xinyu Yang, Qinyu Lu, Qinyu Lu, Qinyu Lu   +17 more
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Detection of myositis-specific antibodies [PDF]

Annals of the Rheumatic Diseases, 2019
It was with much interest that we read the recent European League Against Rheumatism/American College of Rheumatology classification criteria for idiopathic inflammatory myopathies.1 These criteria include Jo-1 autoantibodies, and the authors discussed that future updates of the criteria should also include the more recently identified myositis ...
Jean-Baptiste, Vulsteke, Ellen, De Langhe, Kristl G, Claeys, Doreen, Dillaerts, Koen, Poesen, Jan, Lenaerts, René, Westhovens, Philip, Van Damme, Daniel, Blockmans, Petra, De Haes, Xavier, Bossuyt   +10 more
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