Results 21 to 30 of about 1,873,489 (255)
IgM Antibodies Can Access Cryptic Antigens Denied to IgG: Hypothesis on Novel Binding Mechanism
Frontiers in Immunology, 2019 Antibodies are well-known protein mediators of immunity. IgM is the primordial member and the neglected sibling of the later-evolved and more proficient IgG in regard to their therapeutic and diagnostic use.
Eric Chun Yiu Law +7 more
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Zhongguo shuxue zazhi, 2023 Objective To analyze the factors affecting the efficacy of platelet transfusion and the specificity of HLA-Ⅰ antibodies in tumor patients. Methods Tumer patients applied for platelet transfusion from November 2019 to July 2021 in Sichuan Cancer Hospital ...
Juan SAI, Shanshan WAN, Li TIAN
doaj +1 more source
A disruptive clickable antibody design for the generation of antibody-drug conjugates
, 2023 298310Background: Antibody-drug conjugates are cancer therapeutics that combine specificity and toxicity. A highly cytotoxic drug is covalently attached to an antibody that directs it to cancer cells. The conjugation of the drug-linker to the antibody is
Miriam-Kousso Assi +11 more
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Cautionary notes on the use of NF-κB p65 and p50 antibodies for CNS studies
Journal of Neuroinflammation, 2011 Background The characterization and cellular localization of transcription factors like NF-κB requires the use of antibodies for western blots and immunohistochemistry.
Listwak Samuel J +3 more
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Frontiers in Immunology, 2020 In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear.
Andrew J. Kinloch +8 more
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Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity [PDF]
, 2005 When purified under rigorous conditions, some murine anti-double-stranded-DNA (anti-dsDNA) antibodies actually bind chromatin rather than dsDNA. This suggests that they may actually be antinucleosome antibodies that only appear to bind dsDNA when they ...
Lambrianides, A +13 more
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Specificity of the ChAT antibody.
, 2022 (A) Two nonoverlapping morpholinos blocked the translation of ChAT. (B) Using the same antigen, we made an anti-ChAT antibody in a rabbit. Although the background was slightly high, the antibody recognized ciliary band neurons to a similar degree as a ...
Shunsuke Yaguchi (32970) +4 more
core +1 more source
eLife, 2020 Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high affinity, yet some maintain an additional basal level of low affinity, broad reactivity
Christopher T Boughter +6 more
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Structurally Mapping Antibody Repertoires
Frontiers in Immunology, 2018 Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq).
Konrad Krawczyk +16 more
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Antibody-Drug Conjugates for Cancer Therapy
, 2016 Antibody-drug conjugates (ADCs) take advantage of the specificity of a monoclonal antibody to deliver a linked cytotoxic agent directly into a tumour cell.
Sagun Parakh (9493061) +4 more
core +2 more sources