Results 1 to 10 of about 7,219 (115)
NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels [PDF]
PLoS ONE, 2016 Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby contributing to contact hypersensitivity (CHS). However, since NK cells lack antigen receptors that
Horst Vogel, Horst Pick, Werner Held
exaly +2 more sources
Hapten-Specific Cellular Immune Responses in the Elicitation and Sensitization Phases of Murine Contact Hypersensitivity [PDF]
BiomoleculesContact dermatitis (CD) is a common inflammatory skin condition with irritant etiology or a delayed-type hypersensitivity called allergic contact dermatitis (ACD). Contact hypersensitivity (CHS) is a widely used rodent model of ACD and similarly consists
Kornél Molnár +4 more
doaj +2 more sources
Detection and Potency Classification of Pre- and Pro-Haptens Using the SENS-IS Assay: The Role of Metabolically Competent Reconstructed Skin [PDF]
ToxicsSkin sensitisation assessment increasingly relies on non-animal methods, yet the detection and characterisation of substances requiring metabolic activation, such as pre- and pro-haptens, remain challenging for several existing new approach methodologies
Françoise Cottrez +5 more
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An expedient synthesis of 5-n-alkylresorcinols and novel 5-n-alkylresorcinol haptens
Beilstein Journal of Organic Chemistry, 2009 The first synthesis of bioactive long alkyl chain 5-n-alkylresorcinols, present in whole grain products, by a novel modification of the Wittig reaction is described. All the main long chain 5-n-alkylresorcinols present in rye and wheat, including C23 and
Kristiina Wahala, Kirsti Parikka
exaly +2 more sources
Biomarkers to aid in diagnosis of allergic contact dermatitis [PDF]
Frontiers in AllergyAllergic contact dermatitis (ACD) is an increasingly common skin condition characterized by itchy rashes in response to allergens. The most common diagnostic test involves patch testing (PT), but despite the efficacy of PT for identifying and guiding ...
Manuel Sargen +5 more
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Toxins, 2021 Immunochemical methods for mycotoxin analysis require antigens with well-defined structures and antibodies with outstanding binding properties. Immunoreagents for the mycotoxins alternariol and/or alternariol monomethyl ether have typically been obtained
Luis G. Addante-Moya +4 more
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Chemosensors, 2022 Folic acid (FA) and its other forms known as folates are small molecules vital for humans. The high demand for increasingly sensitive methods of measuring folate concentrations is due to the fact that abnormal levels of FA cause severe health disorders ...
Denis O. Novichikhin +4 more
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Immunity, Inflammation and Disease, 2022 Introduction Contact hypersensitivity (CHS), a type of delayed‐type hypersensitivity, is induced by hapten exposure to the skin and mucosa. We previously reported that, in a murine model of CHS, the vaginal mucosa (VM) sensitization showed lower T‐cell ...
Kanako Nakayama +5 more
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Construction of an enantiopure bivalent nicotine vaccine using synthetic peptides. [PDF]
PLoS ONE, 2017 Clinical outcomes of anti-nicotine vaccines may be improved through enhancements in serum antibody affinity and concentration. Two strategies were explored to improve vaccine efficacy in outbred mice: the use of enantiopure haptens and formulation of a ...
David F Zeigler +2 more
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Cosmetics for neonates and infants: haptens in products’ composition
Clinical and Translational Allergy, 2019 Cosmetics and skin care products for neonates and infants are considered as ‘‘hypoallergenic’’, “tested” or ‘‘safe’’. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is ...
Karolina Dumycz +2 more
doaj +1 more source