Alternative Hapten Design for Zearalenone Immunoreagent Generation [PDF]
Toxins, 2022 Appropriate hapten design and synthesis have been identified as critical steps to generate high-performance immunoreagents and to develop sensitive and selective immunoanalytical methods.
Antonio Abad-Fuentes +5 more
doaj +13 more sources
Hapten Design and Monoclonal Antibody to Fluoroacetamide, a Small and Highly Toxic Chemical [PDF]
Biomolecules, 2020 Fluoroacetamide (FAM) is a small (77 Da) and highly toxic chemical, formerly used as a rodenticide and potentially as a poison by terrorists. Poisoning with FAM has occurred in humans, but few reliably rapid detection methods and antidotes have been ...
Ling Yang +7 more
doaj +7 more sources
Development of Methamphetamine Conjugated Vaccine through Hapten Design: In Vitro and In Vivo Characterization [PDF]
Vaccines, 2023 Background: Methamphetamine (METH) substance-use disorder is an ever-growing global health issue with no effective treatment. Anti-METH vaccines are under investigation as an alternative to existing psychological interventions.
Md Kamal Hossain +6 more
doaj +7 more sources
Hapten Design and Antibody Generation for Immunoanalysis of Spirotetramat and Spirotetramat-enol [PDF]
ACS Omega, 2018 Spirotetramat-a tetramic acid insecticide-is rapidly metabolized or degraded to give spirotetramat-enol; so, common residue definitions include the sum of both compounds. In the present study, two spirotetramat-functionalized derivatives (haptens) have been designed to generate immunoreagents to these molecules for rapid immunochemical analysis ...
Ramón E. Cevallos-Cedeño +4 more
doaj +6 more sources
Foods, 2022 This study provides the first design and synthetic protocol for preparing highly sensitive and specific atrazine (ATR) monoclonal antibodies (mAbs). In this work, a previously unreported hapten, 2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine, was ...
Lingyuan Xu +13 more
doaj +8 more sources
Methamphetamine Vaccines: Improvement through Hapten Design. [PDF]
J Med Chem, 2016 Methamphetamine (MA) addiction is a serious public health problem, and current methods to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic. Development of a vaccine targeting MA would provide a complementary strategy to existing behavioral therapies, but this has proven challenging.
Collins KC +3 more
europepmc +4 more sources
The Hapten Design, Monoclonal Antibody Preparation, and Immunoassay Development for Rapid Detection of Isofenphos-Methyl [PDF]
FoodsIsofenphos-methyl (IFP), a highly toxic and persistent organophosphate pesticide (OP), is widely used for soil pest control in crops but poses severe risks to ecological safety and human health because of its environmental accumulation and ...
Yajie Lei +6 more
doaj +2 more sources
Design of Hapten Synthesis and Antibody Characterization of G-group Aflatoxins
Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2021 Food and feed contamination with Aflatoxins pose a serious threat to human health and animal husbandry development and has caused widespread concern, among them, G-group Aflatoxins as the main pollutant has attracted more and more attention.
Yanan Wang
doaj +3 more sources
Haptens Optimization Using Molecular Modeling and Paper-Based Immunosensor for On-Site Detection of Carbendazim in Vegetable Products [PDF]
BiosensorsCarbendazim is a benzimidazole fungicide widely used in the prevention and control of vegetable diseases. However, if misused, it may result in residues in agricultural products, not only reducing vegetable quality but also posing potential risks to ...
Wenjing Chen +7 more
doaj +2 more sources
Rational design of a fluopyram hapten and preparation of bioconjugates and antibodies for immunoanalysis† [PDF]
RSC Advances, 2015 A fluopyram hapten was designed in which insignificant electronic and structural modifications were foreseen and all potentially interacting chemical moieties were maintained.
E. Ceballos-Alcantarilla +4 more
doaj +4 more sources