Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design. [PDF]
J Med Chem, 2013 Presently, there are no FDA-approved medications to treat cocaine addiction. Active vaccination has emerged as one approach to intervene through the rapid sequestering of the circulating drug, thus terminating both psychoactive effects and drug toxicity.
Cai X +5 more
europepmc +4 more sources
Vaccines against Drug Abuse: Morphine-Hapten Design and Synthesis [PDF]
The 23rd International Electronic Conference on Synthetic Organic Chemistry, 2019 Drugs of abuse are small molecules that typically do not induce an antibody response following the administration. To induce antibodies against these kind of molecules, structural changes have to be made to obtain so called “haptens”. The hapten must be coupled to immunogenic proteins, called “carriers”.
István Köteles, Sándor Hosztafi
openaire +2 more sources
A hapten design strategy to enhance the selectivity of monoclonal antibodies against malachite green
Frontiers in Sustainable Food SystemsMalachite green (MG), a triphenylmethane dye, is used in the aquaculture industry as a disinfectant and insect repellent due to its potent bactericidal and pesticidal properties. However, its use poses potential environmental and health risks. This study
Min-Fu Wu +12 more
doaj +3 more sources
Optimization by the 4S Sequential Experimental Design Process of a Competitive Lateral Flow Immunoassay Device for the Detection of Aflatoxin B1 [PDF]
ToxinsAflatoxin B1 (AFB1) is a highly toxic and carcinogenic compound produced by certain fungi (e.g., Aspergillus flavus and Aspergillus parasiticus). Rapid and ultra-sensitive detection methods for AFB1 in various commodities are in high demand.
Simone Cavalera +6 more
doaj +2 more sources
Comparative design of artificial ochratoxin A antigens: conjugation strategies and immunogenicity evaluation for antibody production [PDF]
Frontiers in Veterinary ScienceOchratoxin A (OTA) is a common fungal toxin contaminant in feed that is primarily produced by fungi belonging to the Aspergillus and Penicillium genera.
Li Han +11 more
doaj +2 more sources
Selection and characterization of a DNA aptamer for Patulin and its application in a label-free fluorescence assay for fruit juices [PDF]
One Health AdvancesPatulin (PTL, 154 Da) is a small molecule toxin produced as a mold metabolite. PTL is unstable in animals and is quickly converted to its metabolites. Thus, few successful antibodies were reported even after extensive efforts in hapten design.
Sihan Wang +5 more
doaj +2 more sources
Development of an Ultrasensitive Monoclonal Antibody against Butralin Based on a Novel Hapten Design Strategy [PDF]
ACS OmegaYong-Jun Li +4 more
doaj +2 more sources
Biosensors, 2022 The improper and excessive use in agriculture of chlorpyrifos–methyl (CPSM) and chlorpyrifos–ethyl (CPSE) may affect the health of human beings.
Zi-Hong Xu +10 more
doaj +1 more source
Immunoassay for Natamycin Trace Screening: Bread, Wine and Other Edibles Analysis
Biosensors, 2022 The antifungal drug natamycin (NAT) is widely used in medicine and in the food industry as preservative E235 for a wide variety of foods. The risk of the development of resistance to NAT and its spread in relation to other polyene antibiotics is fraught ...
Maksim A. Burkin +2 more
doaj +1 more source
Exploring the design applications of key emerging materials from natural sciences through a design ideation workshop [PDF]
, 2023 10th Congress of the International Association of Societies of Design Research (IASDR 2023) 9-13 October 2023, Milan, Italy202405 bcchVersion of ...
Wang, X +15 more
core +1 more source