Results 1 to 10 of about 15,133 (160)

Hapten-Based Cancer Immunotherapy: From Immune Activation to Antitumor Activity [PDF]

Cells
Hapten-based immunotherapies represent a promising strategy to enhance the immunogenicity of tumor antigens and promote antitumor immune responses. Chemical conjugation of small haptens to antigens generates novel antigenic determinants that increase ...
Iseulys Richert, Lionel Chalus, Benoit Pinteur, Paul Bravetti, Corinne Tortorelli, George Alzeeb, François Ghiringhelli   +6 more
doaj   +2 more sources

Development of a Polyclonal Antibody for the Immunoanalysis of Ochratoxin A (OTA) by Employing a Specially Designed Synthetic OTA Derivative as the Immunizing Hapten [PDF]

Toxins
We report herein the development of a polyclonal antibody against ochratoxin A (OTA) using a specially designed synthetic OTA derivative as the immunizing hapten.
Chrysoula-Evangelia Karachaliou, Christos Zikos, Christos Liolios, Maria Pelecanou, Evangelia Livaniou   +4 more
doaj   +2 more sources

Alternative Hapten Design for Zearalenone Immunoreagent Generation

Toxins, 2022
Appropriate hapten design and synthesis have been identified as critical steps to generate high-performance immunoreagents and to develop sensitive and selective immunoanalytical methods.
Antonio Abad-Fuentes, Consuelo Agulló, Daniel López-Puertollano, Ismael Navarro-Fuertes, Antonio Abad-Somovilla, Josep Vicent Mercader   +5 more
doaj   +3 more sources

Sintesis Konjugat Bsa-Hapten Asam 4-(4,6-Diamino-1,3,5-Triazin-2- Ylamino) Butanoat Untuk Pengembangan Deteksi Selektif Melamin

Walisongo Journal of Chemistry, 2020
Sejak isu kontaminasi melamin pada produk susu diketahui secara luas, diperlukan penelitian terbaru tentang teknik pemantauan yang cepat dan akurat untuk mendeteksi melamin dalam produk susu.
Leni Legasari
doaj   +1 more source

Generation of a Recombinant scFv against Deoxycholic Acid and Its Conversion to a Quenchbody for One-Step Immunoassay

Methods and Protocols, 2023
Development of a rapid detection method for deoxycholic acid (DCA) is crucial for its diagnosis in the early stages of inflammation and cancer.
Hiroshi Ueda, Hee-Jin Jeong
doaj   +1 more source

Preparation, Identification and Preliminary Application of the Fenvalerate Monoclonal Antibody in Six Kinds of Dark Tea

Foods, 2023
Fenvalerate has the advantages of a broad insecticidal spectrum, high efficiency, low toxicity and low cost, and it is widely used in agriculture, especially in tea, resulting in the accumulation of fenvalerate residues in tea and the environment, posing
Kang Wei, Qihui Yang, Yang Wei, Yuanfeng Wang, Naifeng Xu, Xinlin Wei   +5 more
doaj   +1 more source

Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides

Frontiers in Immunology, 2021
Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions.
Montserrat Puig, Suryatheja Ananthula, Ramesh Venna, Swamy Kumar Polumuri, Elliot Mattson, Lacey M. Walker, Marco Cardone, Mayumi Takahashi, Shan Su, Lisa F. Boyd, Kannan Natarajan, Galina Abdoulaeva, Wells W. Wu, Gregory Roderiquez, William H. Hildebrand, Serge L. Beaucage, Zhihua Li, David H. Margulies, Michael A. Norcross   +18 more
doaj   +1 more source

Obtaining a Monoclonal Antibody against a Novel Prometryn-Like Hapten and Characterization of Its Selectivity for Triazine Herbicides

Biosensors, 2022
In this study, a previously unreported 3-((4-(isopropylamino)-6-(methylthio)-1,3,5-triazin-2-yl) amino) butyric acid hapten was designed and synthesized.
Lingyuan Xu, A. M. Abd El-Aty, Jing Zhao, Xingmei Lei, Xiuyuan Zhang, Yun Zhao, Xueyan Cui, Yongxin She, Fen Jin, Jing Wang, Maojun Jin, Bruce D. Hammock   +11 more
doaj   +1 more source

Immunoassay Development for the Class-Specific Assay for Types I and II Pyrethroid Insecticides in Water Samples

Molecules, 2010
Five generic haptens of pyrethoid insecticides, which were classified as three types, were designed and synthesized: the first (hapten 1) is for type I pyrethroids without a cyano group, the second (hapten 2 and XQ) for type II pyrethroids with a cyano ...
Peiwu Li, Xiuping Wang, Wen Zhang, Qi Zhang   +3 more
doaj   +1 more source

Synthesis of a psilocin hapten and a protein-hapten conjugate

Journal of Pharmacy and Pharmacology, 2002
Abstract Derivatives of psilocin with ω-functionalized alkyl spacers in position 1 of the indole ring were synthesized as haptens for use in a radioimmunoassay. Whereas the psilocin analogues with a 3-aminopropyl and a 4-aminobutyl moiety at the indole nitrogen decomposed during synthesis, the analogous 3-carboxypropyl psilocin ...
Christian, Albers, Matthias, Lehr, Justus, Beike, Helga, Köhler, Bernd, Brinkmann   +4 more
openaire   +2 more sources