Results 1 to 10 of about 15,180 (184)
Frontiers in Immunology, 2023 For a long time, people have suffered from uncertainty, complexity, and a low success rate in generating and screening antibodies against small molecules, which have become the core bottlenecks of immunochemistry.
Xiangning Han +10 more
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Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
Nature Communications, 2018 Efficient tumor antigen uptake by dendritic cells is facilitated by antibody coating of tumor cells. Here, the authors develop an approach based on hapten vaccination and hapten/tumor targeting ligand conjugates that potentiate anti-tumor immunity by ...
Brett Schrand +7 more
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Characterization of a Single Chain Fv Antibody that Reacts with Free Morphine
Antibodies, 2013 An immune phage library derived from mice, hyperimmunized with morphine-conjugated BSA, was used to isolate a single-chain Fv (scFv) clone, M86, with binding activity to morphine-conjugated thyroglobulin (morphine-C-Tg) but not to codeine-, cocaine-, or ...
Kazuhisa Sugimura +6 more
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Frontiers in Toxicology, 2022 The immunological response in contact hypersensitivity is incited by small electrophilic compounds, known as haptens, that react with endogenous proteins after skin absorption. However, the identity of hapten-modified proteins seen as immunogenic remains
Lorena Ndreu +3 more
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Molecules, 2019 The structure of hapten determines the performance of the antibody and the corresponding detection method. A new type of antigen was designed and synthesized to expose the spatial and characteristic structure of dinotefuran molecule, and a type of high ...
Fangfang Zhao, Jingkun Liu, Jinhui Luo
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Frontiers in Molecular Biosciences, 2021 Antibodies are well known for their high specificity that has enabled them to be of significant use in both therapeutic and diagnostic applications. Antibodies can recognize different antigens, including proteins, carbohydrates, peptides, nucleic acids ...
Mohammed M. Al Qaraghuli +5 more
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An immunoassay for dibutyl phthalate based on direct hapten linkage to the polystyrene surface of microtiter plates. [PDF]
PLoS ONE, 2011 BACKGROUND: Dibutyl phthalate (DBP) is predominantly used as a plasticizer inplastics to make them flexible. Extensive use of phthalates in both industrial processes and other consumer products has resulted in the ubiquitous presence of phthalates in the
Chenxi Wei +6 more
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Case Reports in Dermatology, 2021 Contact immunotherapy with several sensitizing chemicals such as diphenylcyclopropenone (DPCP) or squaric acid dibutyl ester (SADBE) have been used for the treatment of recalcitrant or multiple warts. Here, we report a case of multiple verrucae vulgaris (
Gyohei Egawa +2 more
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Drug and Chemical Allergy: A Role for a Specific Naive T-Cell Repertoire?
Frontiers in Immunology, 2021 Allergic reactions to drugs and chemicals are mediated by an adaptive immune response involving specific T cells. During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells.
Rami Bechara +2 more
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Cutaneous drug hypersensitivity : Immunological and genetic perspective
Indian Journal of Dermatology, 2011 Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of "hapten concept" in immune sensitization has recently been contested by the "pharmacological interaction"
Kisalay Ghosh +3 more
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