Results 31 to 40 of about 15,180 (184)

A chemically contiguous hapten approach for a heroin–fentanyl vaccine

Beilstein Journal of Organic Chemistry, 2019
Background: Increased death due to the opioid epidemic in the United States has necessitated the development of new strategies to treat addiction. Monoclonal antibodies and antidrug vaccines provide a tool that both aids addiction management and reduces ...
Yoshihiro Natori, Candy S. Hwang, Lucy Lin, Lauren C. Smith, Bin Zhou, Kim D. Janda   +5 more
doaj   +1 more source

Synthesis of Polyclonal Antibodies against Aflatoxin B1

Makara Journal of Science, 2015
Polyclonal antibodies of aflatoxin B1 were successfully produced from New Zealand White female rabbits after immunization by the hapten of aflatoxin B1-carboxymethyl hydroxylamine hemihydrochloride (AFB1-CMO) conjugated with bovine serum albumin (BSA) as
Wiyogo Prio Wicaksono, Deni Samsudin Permana, Romsyah Maryam, Yasuaki Einaga   +3 more
doaj   +1 more source

Preparation of Monoclonal Antibodies Specifically Reacting with the Trichothecene Mycotoxins Nivalenol and 15-Acetylnivalenol via the Introduction of a Linker Molecule into Its C-15 Position

Toxins, 2022
Nivalenol (NIV) is a trichothecene mycotoxin that is more toxic than deoxynivalenol. It accumulates in grains due to infection with Fusarium species, which are the causative agents of scab or Fusarium head blight.
Kyoko Noda, Yuki Hirakawa, Tomomi Nishino, Ritsuto Sekizuka, Marin Kishimoto, Tomohiro Furukawa, Sakiko Sawane, Ayu Matsunaga, Naoki Kobayashi, Kazutoshi Sugita, Kenji Oonaka, Hiroko Kawakami, Yuji Otsuka, Tetsuya Yamamoto, Toshihiro Yamamoto, Taku Yoshiya, Maiko Watanabe, Machiko Saka, Keiko Momma, Masayo Kushiro, Shiro Miyake   +20 more
doaj   +1 more source

Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity

Journal of Immunology Research, 2014
Haptens are small molecule irritants that bind to proteins and elicit an immune response. Haptens have been commonly used to study allergic contact dermatitis (ACD) using animal contact hypersensitivity (CHS) models.
Dan A. Erkes, Senthamil R. Selvan
doaj   +1 more source

Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation

Biology, 2023
Haptens are small molecules that only elicit an immune response when bound to proteins. Haptens initially bind to self-proteins and activate innate immune responses by complex mechanisms via inflammatory cytokines and damage-associated molecular patterns
Eri Sakamoto, Yasuhiro Katahira, Izuru Mizoguchi, Aruma Watanabe, Yuma Furusaka, Ami Sekine, Miu Yamagishi, Jukito Sonoda, Satomi Miyakawa, Shinya Inoue, Hideaki Hasegawa, Kazuyuki Yo, Fumiya Yamaji, Akemi Toyoda, Takayuki Yoshimoto   +14 more
doaj   +1 more source

Development of Methamphetamine Conjugated Vaccine through Hapten Design: In Vitro and In Vivo Characterization

Vaccines, 2023
Background: Methamphetamine (METH) substance-use disorder is an ever-growing global health issue with no effective treatment. Anti-METH vaccines are under investigation as an alternative to existing psychological interventions.
Md Kamal Hossain, Majid Davidson, Jack Feehan, George Deraos, Kulmira Nurgali, John Matsoukas, Vasso Apostolopoulos   +6 more
doaj   +1 more source

Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants

Molecules, 2020
Vaccination could be a promising alternative warfare against drug addiction and abuse. For this purpose, so-called haptens can be used. These molecules alone do not induce the activation of the immune system, this occurs only when they are attached to an
István Köteles, Károly Mazák, Gergő Tóth, Boglárka Tűz, Sándor Hosztafi   +4 more
doaj   +1 more source

Novel Aflatoxin Derivatives and Protein Conjugates

Molecules, 2007
Aflatoxins, a group of structurally related mycotoxins, are well known for their toxic and carcinogenic effects in humans and animals. Aflatoxin derivatives and protein conjugates are needed for diverse analytical applications.
Christian Cervino, Dietmar Knopp, Michael G Weller, Reinhard Niessner   +3 more
doaj   +1 more source

Extrinsic Cotton Effects in Hapten—Carrier and Hapten—Antibody Interactions [PDF]

Proceedings of the National Academy of Sciences, 1971
Two homogeneous univalent hapten-protein conjugates, prepared by the covalent attachment of a single 2,4-dinitrophenyl (DNP-) or 2,4,6-trinitrophenyl (TNP-) side chain to the cysteine-SH in the active site of the enzyme papain, have been found to exhibit large Cotton effects in the wavelength region of the absorption bands of the DNP or TNP groups ...
V, Reid, M, Glaser, R, Kennett, S J, Singer   +3 more
openaire   +2 more sources

Estradiol 17β-hemisuccinate: an improved procedure

Journal of Lipid Research, 1972
A simple, rapid, high-yield, and relatively inexpensive procedure for the preparation of estradiol 17β-hemisuccinate is described. The synthesis can be done conveniently in the ordinary biological laboratory.
Tobias O. Yellin
doaj   +1 more source