Results 31 to 40 of about 21,916 (222)

Preparation of Monoclonal Antibodies Specifically Reacting with the Trichothecene Mycotoxins Nivalenol and 15-Acetylnivalenol via the Introduction of a Linker Molecule into Its C-15 Position

Toxins, 2022
Nivalenol (NIV) is a trichothecene mycotoxin that is more toxic than deoxynivalenol. It accumulates in grains due to infection with Fusarium species, which are the causative agents of scab or Fusarium head blight.
Kyoko Noda, Yuki Hirakawa, Tomomi Nishino, Ritsuto Sekizuka, Marin Kishimoto, Tomohiro Furukawa, Sakiko Sawane, Ayu Matsunaga, Naoki Kobayashi, Kazutoshi Sugita, Kenji Oonaka, Hiroko Kawakami, Yuji Otsuka, Tetsuya Yamamoto, Toshihiro Yamamoto, Taku Yoshiya, Maiko Watanabe, Machiko Saka, Keiko Momma, Masayo Kushiro, Shiro Miyake   +20 more
doaj   +1 more source

Hapten-Specific Single-Cell Selection of Hybridoma Clones by Fluorescence-Activated Cell Sorting for the Generation of Monoclonal Antibodies

, 2017
The conventional hybridoma screening and subcloning process is generally considered to be one of the most critical steps in hapten-specific antibody production.
Schenk, J. A., Kuhne, Maren, Hoffmann, Katrin, Dippong, Martin, Lenz, C., Peter Carl, Maren Kuhne, Rudolf J. Schneider (3699694), Schneider, Rudolf, Schwaar, Timm, Lenz, Christine, Katrin Hoffmann, Martin Dippong (1857256), Timm Schwaar, Jörg A. Schenk, Martin Dippong, Schenk, Jörg A., Carl, Peter, Timm Schwaar (1514116), Katrin Hoffmann (17460), Jörg A. Schenk (3852733), Schneider, Rudolf J., Maren Kuhne (58602), Rudolf J. Schneider, Christine Lenz, Peter Carl (3852736), Christine Lenz (244370)   +26 more
core   +1 more source

What’s been Hapten-ing over the last 88 years?

, 2023
Definition of the relationship between drug protein adduct formation (haptenation) and development of immunological adverse drug reactions (drug hypersensitivity) has been an area of active research for over 80 years.
Dean J. Naisbitt, Naisbitt, Dean J, Hammond, Sean, Sean Hammond, Xiaoli Meng, Meng, Xiaoli, Paul Thomson, Thomson, Paul   +7 more
core   +1 more source

COMPETITION OF HASTENS [PDF]

The Journal of Experimental Medicine, 1966
Groups of rabbits were injected with either bovine serum albumin, sheep red cell stroma, or keyhole limpet hemocyanin to which 2,4-dinitrophenyl and/or p-azophenyl arsonate groups had been coupled. Groups of animals received either doubly coupled antigen or an equivalent mixture of singly coupled antigens.
Amkraut, Alfred A., Garvey, Justine S., Campbell, Dan H.   +2 more
openaire   +3 more sources

Hapten-Grafted Programmed Probe as a Corecognition Element for a Competitive Immunosensor to Detect Acetamiprid Residue in Agricultural Products

, 2018
We have developed an effective competitive electrochemical immunosensor assay based on hapten-grafted programmed probe (HGPP) as a corecognition element for highly sensitive and selective detection of acetamiprid.
Yuna Guo (780568), Yirong Guo (630966), Sundaram Gunasekaran (1473790), Xiahong Xu (1940557), Liu Wang (213066), Kaiyu He (469662), Xinquan Wang (211905)   +6 more
core   +1 more source

Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation

Biology, 2023
Haptens are small molecules that only elicit an immune response when bound to proteins. Haptens initially bind to self-proteins and activate innate immune responses by complex mechanisms via inflammatory cytokines and damage-associated molecular patterns
Eri Sakamoto, Yasuhiro Katahira, Izuru Mizoguchi, Aruma Watanabe, Yuma Furusaka, Ami Sekine, Miu Yamagishi, Jukito Sonoda, Satomi Miyakawa, Shinya Inoue, Hideaki Hasegawa, Kazuyuki Yo, Fumiya Yamaji, Akemi Toyoda, Takayuki Yoshimoto   +14 more
doaj   +1 more source

Hapten-specific ear swelling effect differences between sensitization periods and time of data collection.

, 2019
While 7, 21 and 32 day sensitization periods yielded significant hapten-specific inflammation responses, the 32 day sensitization period showed the largest effect of prior sensitization.
J. Hostetter (7481327), S. Charley (7481315), C. L. Loving (7481330), M. Palmer (7481321), A. Boettcher (7481312), A. M. Putz (7481309), C. K. Tuggle (7481336), J. E. Cunnick (7481333), E. J. Putz (7481306), M. Sauer (7481318), R. Phillips (7481324)   +10 more
core   +1 more source

Development of Methamphetamine Conjugated Vaccine through Hapten Design: In Vitro and In Vivo Characterization

Vaccines, 2023
Background: Methamphetamine (METH) substance-use disorder is an ever-growing global health issue with no effective treatment. Anti-METH vaccines are under investigation as an alternative to existing psychological interventions.
Md Kamal Hossain, Majid Davidson, Jack Feehan, George Deraos, Kulmira Nurgali, John Matsoukas, Vasso Apostolopoulos   +6 more
doaj   +1 more source

Novel Aflatoxin Derivatives and Protein Conjugates

Molecules, 2007
Aflatoxins, a group of structurally related mycotoxins, are well known for their toxic and carcinogenic effects in humans and animals. Aflatoxin derivatives and protein conjugates are needed for diverse analytical applications.
Christian Cervino, Dietmar Knopp, Michael G Weller, Reinhard Niessner   +3 more
doaj   +1 more source

Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants

Molecules, 2020
Vaccination could be a promising alternative warfare against drug addiction and abuse. For this purpose, so-called haptens can be used. These molecules alone do not induce the activation of the immune system, this occurs only when they are attached to an
István Köteles, Károly Mazák, Gergő Tóth, Boglárka Tűz, Sándor Hosztafi   +4 more
doaj   +1 more source