Results 51 to 60 of about 21,916 (222)

Characterization of a Single Chain Fv Antibody that Reacts with Free Morphine

Antibodies, 2013
An immune phage library derived from mice, hyperimmunized with morphine-conjugated BSA, was used to isolate a single-chain Fv (scFv) clone, M86, with binding activity to morphine-conjugated thyroglobulin (morphine-C-Tg) but not to codeine-, cocaine-, or ...
Kazuhisa Sugimura, Yuta Hamazoe, Koji Arizono, Shinya Kohra, Koichi Tanaka, Mariko Kamegawa, Miho Matsukizono   +6 more
doaj   +1 more source

Haptenation of Macrophage Migration Inhibitory Factor: A Potential Biomarker for Contact Hypersensitivity

Frontiers in Toxicology, 2022
The immunological response in contact hypersensitivity is incited by small electrophilic compounds, known as haptens, that react with endogenous proteins after skin absorption. However, the identity of hapten-modified proteins seen as immunogenic remains
Lorena Ndreu, Samantha Sasse, Ann-Therese Karlberg, Isabella Karlsson   +3 more
doaj   +1 more source

Extrinsic Cotton Effects in Hapten—Carrier and Hapten—Antibody Interactions [PDF]

Proceedings of the National Academy of Sciences, 1971
Two homogeneous univalent hapten-protein conjugates, prepared by the covalent attachment of a single 2,4-dinitrophenyl (DNP-) or 2,4,6-trinitrophenyl (TNP-) side chain to the cysteine-SH in the active site of the enzyme papain, have been found to exhibit large Cotton effects in the wavelength region of the absorption bands of the DNP or TNP groups ...
V, Reid, M, Glaser, R, Kennett, S J, Singer   +3 more
openaire   +2 more sources

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Synthesis of Hapten 9.

, 2013
Synthesis of Hapten 9.
Heather L. Davis (465261), Phil White (465256), James R. Merson (465260), Lyn H. Jones (465244), Alan D. Brown (465249), Michelle Benoit (465258), David C. Pryde (353590), Yvonne Wharton (465254), Jotham W. Coe (465250), Ningli Zhang (465257), David P. Gervais (465245), David C. Blakemore (465247), Rebecca Glen (465253), Matthew Badland (465251), Gavin J. Miller (465255), David M. Beal (465252), Michael J. McCluskie (465262), David R. Stead (465246), Matthew D. Selby (465248), Karen Robertson (465259)   +19 more
core   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

Synthesis of Hapten 8.

, 2013
Synthesis of Hapten 8.
Heather L. Davis (465261), Phil White (465256), James R. Merson (465260), Lyn H. Jones (465244), Alan D. Brown (465249), Michelle Benoit (465258), David C. Pryde (353590), Yvonne Wharton (465254), Jotham W. Coe (465250), Ningli Zhang (465257), David P. Gervais (465245), David C. Blakemore (465247), Rebecca Glen (465253), Matthew Badland (465251), Gavin J. Miller (465255), David M. Beal (465252), Michael J. McCluskie (465262), David R. Stead (465246), Matthew D. Selby (465248), Karen Robertson (465259)   +19 more
core   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Hapten Application to the Skin Induces an Inflammatory Program Directing Hapten-Primed Effector CD8 T Cell Interaction with Hapten-Presenting Endothelial Cells

, 2011
Contact hypersensitivity is a CD8 T cell-mediated response to hapten sensitization and challenge of the skin. Effector CD8 T cell recruitment into the skin parenchyma to elicit the response to hapten challenge requires prior CXCL1/KC-directed neutrophil ...
Nina Volokh, Robert L. Fairchild, Danielle D. Kish, William M. Baldwin   +3 more
core   +1 more source

Local and Systemic Desensitization Induced by Repeated Epicutaneous Hapten Application [PDF]

, 1987
Frequent skin exposure of guinea pigs to the contact sensitizing agents dinitrochlorobenzene or 4-ethoxymethylene-2-phenyloxazolone induced both systemic hyposensitization and local unresponsiveness within 8 weeks.
Gijs H. Boerrigter, Boerrigter, Gijs H., Rik J. Scheper, Scheper, Rik J.   +3 more
core   +1 more source