Results 21 to 30 of about 8,472 (222)
Experimental Biology and Medicine, 1926 Abstract In attempting to purify the specific part of the heterogenetic haptene, present in alcoholic extracts of horse kidneys, fractions were obtained which are distinguished from the common lipoids by their solubility in water. The material of one fraction described recently3 is practically insoluble in alcohol, chloroform and ether ...
K Landsteiner, P A Levene
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Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation
Biology, 2023 Haptens are small molecules that only elicit an immune response when bound to proteins. Haptens initially bind to self-proteins and activate innate immune responses by complex mechanisms via inflammatory cytokines and damage-associated molecular patterns
Eri Sakamoto +14 more
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Alternative Hapten Design for Zearalenone Immunoreagent Generation
Toxins, 2022 Appropriate hapten design and synthesis have been identified as critical steps to generate high-performance immunoreagents and to develop sensitive and selective immunoanalytical methods.
Antonio Abad-Fuentes +5 more
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Antibodies, 2022 Yeast surface display techniques have been increasingly employed as a tool for both the discovery and affinity maturation of antibodies. In this study, we describe the use of yeast surface display for the selection and affinity maturation of antibodies ...
Bhupal Ban +2 more
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Opioid-Based Haptens: Development of Immunotherapy. [PDF]
Int J Mol SciOver the past decades, extensive preclinical research has been conducted to develop vaccinations to protect against substance use disorder caused by opioids, nicotine, cocaine, and designer drugs. Morphine or fentanyl derivatives are small molecules, and
Hosztafi S +5 more
europepmc +2 more sources
Novel mouse model of colitis characterized by hapten-protein visualization
BioTechniques, 2010 Trinitrobenzene sulfonic acid (TNBS) and oxazolone are used to induce colitis for the investigation of inflammatory reactions in the colon. Although these chemicals are presumed to bind proteins in the colonic mucosa and then induce colitis as haptens ...
Kazuhiro Ishiguro +4 more
doaj +1 more source
An expedient synthesis of 5-n-alkylresorcinols and novel 5-n-alkylresorcinol haptens
Beilstein Journal of Organic Chemistry, 2009 The first synthesis of bioactive long alkyl chain 5-n-alkylresorcinols, present in whole grain products, by a novel modification of the Wittig reaction is described. All the main long chain 5-n-alkylresorcinols present in rye and wheat, including C23 and
Kirsti Parikka, Kristiina Wähälä
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Single-Domain Antibodies As Versatile Affinity Reagents for Analytical and Diagnostic Applications
Frontiers in Immunology, 2017 With just three CDRs in their variable domains, the antigen-binding site of camelid heavy-chain-only antibodies (HcAbs) has a more limited structural diversity than that of conventional antibodies.
Gualberto Gonzalez-Sapienza +2 more
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[Translated article] Haptens, Proteins, and Atopic Dermatitis
Actas Dermo-Sifiliográficas, 2023 Atopic dermatitis is a chronic inflammatory disease that is multifactorial in nature. Allergic contact dermatitis and protein contact dermatitis are allergic conditions that may occur in the context of atopic dermatitis and be the cause of exacerbations.
V. Amat-Samaranch +1 more
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Role of hydrophobic interaction in hapten-antibody binding
, 1977 The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more
Oda, Takuzo +5 more
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