NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels [PDF]
PLoS ONE, 2016 Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby contributing to contact hypersensitivity (CHS). However, since NK cells lack antigen receptors that
Horst Vogel, Horst Pick, Werner Held
exaly +4 more sources
Assessment of the Optimum Linker Tethering Site of Alternariol Haptens for Antibody Generation and Immunoassay Development [PDF]
Toxins, 2021 Immunochemical methods for mycotoxin analysis require antigens with well-defined structures and antibodies with outstanding binding properties. Immunoreagents for the mycotoxins alternariol and/or alternariol monomethyl ether have typically been obtained
Luis G. Addante-Moya +4 more
doaj +2 more sources
Cosmetics for neonates and infants: haptens in products’ composition [PDF]
Clinical and Translational Allergy, 2019 Cosmetics and skin care products for neonates and infants are considered as ‘‘hypoallergenic’’, “tested” or ‘‘safe’’. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is ...
Karolina Dumycz +2 more
doaj +2 more sources
Hapten-Specific Cellular Immune Responses in the Elicitation and Sensitization Phases of Murine Contact Hypersensitivity [PDF]
BiomoleculesContact dermatitis (CD) is a common inflammatory skin condition with irritant etiology or a delayed-type hypersensitivity called allergic contact dermatitis (ACD). Contact hypersensitivity (CHS) is a widely used rodent model of ACD and similarly consists
Kornél Molnár +4 more
doaj +2 more sources
Biomarkers to aid in diagnosis of allergic contact dermatitis [PDF]
Frontiers in AllergyAllergic contact dermatitis (ACD) is an increasingly common skin condition characterized by itchy rashes in response to allergens. The most common diagnostic test involves patch testing (PT), but despite the efficacy of PT for identifying and guiding ...
Manuel Sargen +5 more
doaj +2 more sources
Synthesis of haptens and production of antibodies to bisphenol A [PDF]
Frontiers of Agricultural Science and Engineering, 2017 Three immunizing haptens of bisphenol A (BPA), including two new haptens, were used to produce highly sensitive and specific polyclonal antibodies. The spacer arms of haptens for coupling to the protein carrier were located at different positions in BPA,
Xiya ZHANG, Xiaoyun DONG, Sijun ZHAO, Yuebin KE, Kai WEN, Suxia ZHANG, Zhanhui WANG, Jianzhong SHEN
doaj +3 more sources
Design, Synthesis, and In Vivo Evaluation of C1-Linked 4,5-Epoxymorphinan Haptens for Heroin Vaccines [PDF]
Molecules, 2022 In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap (1), 1-AmidoMorHap epimer (2), 1 Amido ...
Agnieszka Sulima +13 more
doaj +2 more sources
Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine [PDF]
Biomolecules, 2019 Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies ...
Lin Luo +9 more
doaj +3 more sources
Biological Activity of the Carrier as a Factor in Immunogen Design for Haptens [PDF]
Molecules, 2018 Immunoanalytical methods are frequently employed in the detection of hazardous small molecular weight compounds. However, antibody development for these molecules is a challenge, because they are haptens and cannot induce a humoral immune response in ...
Özlem Ertekin +3 more
doaj +2 more sources
Unveil the molecular recognition mechanisms of triazine haptens and monoclonal antibodies: Establishing ic‐ELISA methods for triazine herbicide analysis in tea [PDF]
Food Safety and HealthThis study introduced two triazine haptens (with 0 or 1 carbon connecting arms at nonisopropyl positions) and developed two heterologous indirect competitive enzyme‐linked immunosorbent assay (ic‐ELISA) methods.
Lingyuan Xu +12 more
doaj +2 more sources