Results 11 to 20 of about 8,472 (222)

Synthesis of haptens and production of antibodies to bisphenol A [PDF]

Frontiers of Agricultural Science and Engineering, 2017
Three immunizing haptens of bisphenol A (BPA), including two new haptens, were used to produce highly sensitive and specific polyclonal antibodies. The spacer arms of haptens for coupling to the protein carrier were located at different positions in BPA,
Xiya ZHANG, Xiaoyun DONG, Sijun ZHAO, Yuebin KE, Kai WEN, Suxia ZHANG, Zhanhui WANG, Jianzhong SHEN
doaj   +2 more sources

Formulation of unavailable diagnostic haptens for the detection of contact allergy to topical medications in the Polish Baseline Series

Alergologia Polska
The necessity of routine patch testing to topical medications reflects the frequency of contact allergy to these haptens as well as their presence in many popular medicinal products. At present, Polish Baseline Series includes 7 drugs tested individually
Radosław Śpiewak, Aldona Maciejewska, Krzysztof Niwiński   +2 more
doaj   +2 more sources

Design, Synthesis, and In Vivo Evaluation of C1-Linked 4,5-Epoxymorphinan Haptens for Heroin Vaccines

Molecules, 2022
In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap (1), 1-AmidoMorHap epimer (2), 1 Amido ...
Agnieszka Sulima, Fuying Li, Jeffrey Brian Morgan, Phong Truong, Joshua F. G. Antoline, Therese Oertel, Rodell C. Barrientos, Oscar B. Torres, Zoltan Beck, Gregory H. Imler, Jeffrey R. Deschamps, Gary R. Matyas, Arthur E. Jacobson, Kenner C. Rice   +13 more
doaj   +2 more sources

Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine [PDF]

Biomolecules, 2019
Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies ...
Lin Luo, Xiao-Qun Wei, Bao-Zhu Jia, Jin-Yi Yang, Yu-Dong Shen, Bruce Hammock, Jie-Xian Dong, Hong Wang, Hong-Tao Lei, Zhen-Lin Xu   +9 more
doaj   +2 more sources

Biological Activity of the Carrier as a Factor in Immunogen Design for Haptens

Molecules, 2018
Immunoanalytical methods are frequently employed in the detection of hazardous small molecular weight compounds. However, antibody development for these molecules is a challenge, because they are haptens and cannot induce a humoral immune response in ...
Özlem Ertekin, Esin Akçael, Harun Kocaağa, Selma Öztürk   +3 more
doaj   +2 more sources

Portrait of an autologous cancer vaccine: Then and now

Human Vaccines & Immunotherapeutics, 2023
Active immunotherapy of cancer with therapeutic vaccines has been the subject of experimental and clinical studies for at least 50 years. Our approach has employed 1) autologous, human cancer cells because of extensive evidence that tumor rejection ...
David Berd
doaj   +1 more source

Synthesis of a psilocin hapten and a protein-hapten conjugate

Journal of Pharmacy and Pharmacology, 2002
Abstract Derivatives of psilocin with ω-functionalized alkyl spacers in position 1 of the indole ring were synthesized as haptens for use in a radioimmunoassay. Whereas the psilocin analogues with a 3-aminopropyl and a 4-aminobutyl moiety at the indole nitrogen decomposed during synthesis, the analogous 3-carboxypropyl psilocin ...
Christian, Albers, Matthias, Lehr, Justus, Beike, Helga, Köhler, Bernd, Brinkmann   +4 more
openaire   +2 more sources

Structural Basis for Trivalent Cross-Linking of a Patient-Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201. [PDF]

Allergy
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Parkkinen T, Heiniluoto H, Jänis J, Takkinen K, Rouvinen J.   +4 more
europepmc   +2 more sources

Consequences of drug binding to immune receptors: Immune stimulation following pharmacological interaction with immune receptors (T-cell receptor for antigen or human leukocyte antigen) with altered peptide-human leukocyte antigen or peptide

Dermatologica Sinica, 2013
Drugs may stimulate the immune system by forming hapten–carrier complexes or via their pharmacological features, namely by noncovalent binding to proteins such as immune receptors.
Werner J. Pichler
doaj   +1 more source

Contact allergens in moisturizers in preventative emollient therapy – A systematic review

Clinical and Translational Allergy, 2022
Background Results of preventative emollient therapy on atopic dermatitis and food allergy trials are inconsistent. In addition to the ingredients considered beneficial, the moisturizers may contain potentially harmful haptens. This study aimed to assess
Klaudia Ryczaj, Karolina Dumycz, Radoslaw Spiewak, Wojciech Feleszko   +3 more
doaj   +1 more source