Results 11 to 20 of about 678,918 (305)
Characterization of a monoclonal antibody with specificity for holo-transcobalamin [PDF]
Nutrition & Metabolism, 2006 Background Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant.
Fedosov Sergey N +7 more
doaj +2 more sources
Antibody-Drug Conjugates for Cancer Therapy [PDF]
, 2023 Antibody-drug conjugates (ADCs) take advantage of the specificity of a monoclonal antibody to deliver a linked cytotoxic agent directly into a tumour cell.
Sagun Parakh (9493061) +4 more
core +3 more sources
A strong case for third-party testing
eLife, 2023 A strategy to identify high-quality commercially available antibodies for research reveals extensive use of non-specific antibodies and offers solutions for future large-scale testing.
Fridtjof Lund-Johansen
doaj +1 more source
A disruptive clickable antibody design for the generation of antibody-drug conjugates [PDF]
, 2023 298310Background: Antibody-drug conjugates are cancer therapeutics that combine specificity and toxicity. A highly cytotoxic drug is covalently attached to an antibody that directs it to cancer cells. The conjugation of the drug-linker to the antibody is
Miriam-Kousso Assi +11 more
core +1 more source
Biomolecules, 2020 Alpha7 nicotinic acetylcholine receptors (α7nAChRs) are interesting not only because of their physiological effects, but because this receptor requires chaperones to traffic to cell surfaces (measured by alpha-bungarotoxin [αBGT] binding ...
Anish Deshpande +18 more
doaj +1 more source
Antibody-specific immunoregulation [PDF]
The Journal of Experimental Medicine, 1977 In recent years, much evidence has accumulated which demonstrates that an animal's immune system has the capacity to recognize its own antibody idiotypes. These findings suggest that self-idiotypic recognition may potentially play a role in the regulation of B-cell responses.
S K, Pierce, N R, Klinman
openaire +2 more sources
Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization. [PDF]
Antibodies (Basel)Therapeutic antibodies with lambda light chains (λ-Abs) are underrepresented compared to kappa light chains (κ-Abs). Here, we evaluated two SARS-CoV-2-specific monoclonal antibodies (mAbs) that exhibit high (P5C3) and low (H4) antigen binding as κ and λ ...
Sun L +8 more
europepmc +3 more sources
Frequency of alloantibody with their specification among multitransfused patients
Global Journal of Transfusion Medicine, 2020 Background and Objectives: Alloimmunization is a very common clinical problem in transfusion-dependent patients but rarely detected in Bangladesh.
Ayesha Khatun +4 more
doaj +1 more source
Specificities of Antibodies to Normetanephrine [PDF]
European Journal of Biochemistry, 1972 Antibodies to normetanephrine were produced in rabbits by immunization with conjugates synthesized by linking the amino group of the hapten to the amino groups of the carrier macromolecules using glutaraldehyde. The antibodies are highly specific for the ring structure of the normetanephrine molecule and also recognize substitutions in the side chain ...
B A, Peskar, B M, Peskar, L, Levine
openaire +2 more sources
Frontiers in Immunology, 2017 Identifying protective synthetic oligosaccharide (OS) epitopes of Streptococcus pneumoniae capsular polysaccharides (CPs) is an indispensable step in the development of third-generation carbohydrate pneumococcal vaccines.
Ekaterina A. Kurbatova +9 more
doaj +1 more source