Results 31 to 40 of about 1,781,035 (303)

Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity [PDF]

, 2005
When purified under rigorous conditions, some murine anti-double-stranded-DNA (anti-dsDNA) antibodies actually bind chromatin rather than dsDNA. This suggests that they may actually be antinucleosome antibodies that only appear to bind dsDNA when they ...
Lambrianides, A, Rahman, A, Anisur Rahman, Isenberg, DA, Mason, LJ, David S Latchman, Lesley J Mason, Manson, JJ, Latchman, DS, Jessica J Manson, David A Isenberg, Joanna D Haley, Haley, JD, Anastasia Lambrianides   +13 more
core   +1 more source

IgM Antibodies Can Access Cryptic Antigens Denied to IgG: Hypothesis on Novel Binding Mechanism

Frontiers in Immunology, 2019
Antibodies are well-known protein mediators of immunity. IgM is the primordial member and the neglected sibling of the later-evolved and more proficient IgG in regard to their therapeutic and diagnostic use.
Eric Chun Yiu Law, Danny Tze Ming Leung, Frankie Chi Hang Tam, Frankie Chi Hang Tam, Kitty Kit Ting Cheung, Naomi Hua Yin Cheng, Pak Leong Lim, Pak Leong Lim   +7 more
doaj   +1 more source

Factors affecting the efficacy of platelet transfusion and specificity of HLA-Ⅰ antibodies in tumor patients

Zhongguo shuxue zazhi, 2023
Objective To analyze the factors affecting the efficacy of platelet transfusion and the specificity of HLA-Ⅰ antibodies in tumor patients. Methods Tumer patients applied for platelet transfusion from November 2019 to July 2021 in Sichuan Cancer Hospital ...
Juan SAI, Shanshan WAN, Li TIAN
doaj   +1 more source

Low specificity of determine HIV1/2 RDT using whole blood in south west Tanzania [PDF]

, 2012
Objective: To evaluate the diagnostic performance of two rapid detection tests (RDTs) for HIV 1/2 in plasma and in whole blood samples. Methods: More than 15,000 study subjects above the age of two years participated in two rounds of a cohort study to ...
Geldmacher Christof, Petra Clowes, Elmar Saathoff, Leonard Maboko, Wolfram Mwalongo, Clowes, Petra, Hoelscher, Michael, Kroidl, Arne L., Geldmacher, Christof, Michael Hoelscher, Arne L Kroidl, Kroidl Arne L., Hoelscher Michael, Harun Machibya, Kroidl, Inge, Machibya Harun, Machibya, Harun, Saathoff, Elmar, Inge Kroidl, Maganga, Lucas, Kroidl Inge, Maganga Lucas, Mwalongo Wolfram, Christof Geldmacher, Maboko Leonard, Mwalongo, Wolfram, Saathoff Elmar, Maboko, Leonard, Lucas Maganga, Clowes Petra   +29 more
core   +2 more sources

Cautionary notes on the use of NF-κB p65 and p50 antibodies for CNS studies

Journal of Neuroinflammation, 2011
Background The characterization and cellular localization of transcription factors like NF-κB requires the use of antibodies for western blots and immunohistochemistry.
Listwak Samuel J, Brown Pierre, Rathore Priyanka, Herkenham Miles   +3 more
doaj   +1 more source

Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation

Frontiers in Immunology, 2020
In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear.
Andrew J. Kinloch, Yuta Asano, Azam Mohsin, Carole Henry, Rebecca Abraham, Anthony Chang, Christine Labno, Patrick C. Wilson, Marcus R. Clark   +8 more
doaj   +1 more source

A disruptive clickable antibody design for the generation of antibody-drug conjugates

, 2023
298310Background: Antibody-drug conjugates are cancer therapeutics that combine specificity and toxicity. A highly cytotoxic drug is covalently attached to an antibody that directs it to cancer cells. The conjugation of the drug-linker to the antibody is
Miriam-Kousso Assi, Simon K Krebs, Stech, Marlitt, Rakotoarinoro, Nathanaël, Krebs, Simon, Nathanaël Rakotoarinoro, Yan F K Dyck, Maria K Parr, Dyck, Yan F.K., Parr, Maria K., Marlitt Stech, Assi, Miriam-Kousso   +11 more
core   +1 more source

Antibody-Drug Conjugates for Cancer Therapy

, 2023
Antibody-drug conjugates (ADCs) take advantage of the specificity of a monoclonal antibody to deliver a linked cytotoxic agent directly into a tumour cell.
Sagun Parakh (9493061), Adam Parslow (9493046), Andrew Scott (9483443), Fook-Thean Lee (9491234), Hui Gan (9477872)   +4 more
core   +2 more sources

Specificities of Antibodies to Normetanephrine [PDF]

European Journal of Biochemistry, 1972
Antibodies to normetanephrine were produced in rabbits by immunization with conjugates synthesized by linking the amino group of the hapten to the amino groups of the carrier macromolecules using glutaraldehyde. The antibodies are highly specific for the ring structure of the normetanephrine molecule and also recognize substitutions in the side chain ...
B A, Peskar, B M, Peskar, L, Levine
openaire   +2 more sources

Antibodies for immunolabeling by light and electron microscopy : not for the faint hearted [PDF]

, 2014
Reliable antibodies represent crucial tools in the arsenal of the cell biologist and using them to localize antigens for immunocytochemistry is one of their most important applications.
Lucocq, John Milton, Griffiths, Gareth
core   +1 more source