Results 31 to 40 of about 651,038 (261)

Factors affecting the efficacy of platelet transfusion and specificity of HLA-Ⅰ antibodies in tumor patients

Zhongguo shuxue zazhi, 2023
Objective To analyze the factors affecting the efficacy of platelet transfusion and the specificity of HLA-Ⅰ antibodies in tumor patients. Methods Tumer patients applied for platelet transfusion from November 2019 to July 2021 in Sichuan Cancer Hospital ...
Juan SAI, Shanshan WAN, Li TIAN
doaj   +1 more source

Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation

Frontiers in Immunology, 2020
In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear.
Andrew J. Kinloch, Yuta Asano, Azam Mohsin, Carole Henry, Rebecca Abraham, Anthony Chang, Christine Labno, Patrick C. Wilson, Marcus R. Clark   +8 more
doaj   +1 more source

Antibodies to guanosine [PDF]

FEBS Letters, 1984
Bovine serum albumin conjugates of guanosine prepared by the periodate method was used as immunogen to elicit guanosine antibodies in rabbits. The specificities of the antibodies were studied by the inhibition of their binding to [3H]Gox‐red, [32P]DNA and [3H]RNA by related non‐radioactive compounds.
Iswari, S, Jacob, TM
openaire   +2 more sources

Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

eLife, 2020
Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high affinity, yet some maintain an additional basal level of low affinity, broad reactivity
Christopher T Boughter, Marta T Borowska, Jenna J Guthmiller, Albert Bendelac, Patrick C Wilson, Benoit Roux, Erin J Adams   +6 more
doaj   +1 more source

Structurally Mapping Antibody Repertoires

Frontiers in Immunology, 2018
Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq).
Konrad Krawczyk, Sebastian Kelm, Aleksandr Kovaltsuk, Jacob D. Galson, Dominic Kelly, Johannes Trück, Johannes Trück, Cristian Regep, Jinwoo Leem, Wing K. Wong, Jaroslaw Nowak, James Snowden, Michael Wright, Laura Starkie, Anthony Scott-Tucker, Jiye Shi, Charlotte M. Deane   +16 more
doaj   +1 more source

Specific Suppression of the Antibody Response by Antibodies to Receptors [PDF]

Proceedings of the National Academy of Sciences, 1972
Balb/c myeloma proteins, TEPC 15 and MOPC 167, bind phosphorylcholine and precipitate with the C-polysaccharide moiety of pneumococci R36A. Anti-idiotypic antibodies to TEPC 15 myeloma raised in A/He mice prevent plaque formation by cells releasing antibody to phosphorylcholine and inhibit induction of the antibody response to ...
Cosenza, H, Kohler, H
openaire   +2 more sources

Molecular chaperone effects on recombinant yield and binding characteristics of an ABA-specific scFv in Escherichia coli

Frontiers in Bioengineering and Biotechnology
IntroductionRecombinant single‐chain variable fragments (scFvs) are promising antibody formats for cost‐effective and scalable production. However, their soluble expression in Escherichia coli is often limited by misfolding and aggregation, particularly ...
Shimiao Chen, Shimiao Chen, Shimiao Chen, Bin Shan, Bin Shan, Yican Luo, Ganhui Mo, Ganhui Mo, Ganhui Mo, Usman Rasheed, Usman Rasheed, Usman Rasheed, Lilan Lv, Lilan Lv, Xinyu Yang, Qinyu Lu, Qinyu Lu, Qinyu Lu   +17 more
doaj   +1 more source

The Complexity of Antibody Responses Elicited against the Respiratory Syncytial Virus Glycoproteins in Hospitalized Children Younger than 2 Years

Frontiers in Microbiology, 2017
The influence of age and maternal antibodies on the antibody responses to human respiratory syncytial virus (hRSV) glycoproteins in very young children has been a matter of controversy.
Alfonsina Trento, Alfonsina Trento, Rosa Rodríguez-Fernández, María I. González-Sánchez, Felipe González-Martínez, Vicente Mas, Vicente Mas, Mónica Vázquez, Mónica Vázquez, Concepción Palomo, Concepción Palomo, José A. Melero, José A. Melero   +12 more
doaj   +1 more source

Antibody variable region engineering for improving cancer immunotherapy

Cancer Communications, 2022
The efficacy and specificity of conventional monoclonal antibody (mAb) drugs in the clinic require further improvement. Currently, the development and application of novel antibody formats for improving cancer immunotherapy have attracted much attention.
Hantao Lou, Xuetao Cao
doaj   +1 more source

Detection of myositis-specific antibodies [PDF]

Annals of the Rheumatic Diseases, 2019
It was with much interest that we read the recent European League Against Rheumatism/American College of Rheumatology classification criteria for idiopathic inflammatory myopathies.1 These criteria include Jo-1 autoantibodies, and the authors discussed that future updates of the criteria should also include the more recently identified myositis ...
Jean-Baptiste, Vulsteke, Ellen, De Langhe, Kristl G, Claeys, Doreen, Dillaerts, Koen, Poesen, Jan, Lenaerts, René, Westhovens, Philip, Van Damme, Daniel, Blockmans, Petra, De Haes, Xavier, Bossuyt   +10 more
openaire   +2 more sources